{"id":"W2053460598","doi":"10.1126/science.1188308","title":"Quantifying <i>E. coli</i> Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells","year":2010,"lang":"en","type":"article","venue":"Science","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Messenger RNA; Biology; Escherichia coli; Transcriptome; Proteome; Single-cell analysis; Transcription (linguistics); Fusion protein; Gene expression; Molecular biology; RNA; Cell; Gene; Uncorrelated; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003466078,0.0002673505,0.0004335243,0.0004335096,0.0001560255,0.0005376294,0.0002502225,0.0003299256,0.0003623316],"category_scores_gemma":[0.0005640688,0.0002162154,0.0002518448,0.0004158367,0.0003146197,0.0003780476,0.0002502538,0.0004812532,0.0001971421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004127686,"about_ca_system_score_gemma":0.0001504814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006508665,"about_ca_topic_score_gemma":0.0007683266,"domain_scores_codex":[0.9997975,0.00003052791,0.00001264181,0.0000901107,0.00005207822,0.00001713426],"domain_scores_gemma":[0.9996986,0.0001480415,0.00005252339,0.00003383118,0.00004262001,0.00002427021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002618498,0.0000055541,0.0008958178,0.00003151192,0.000006567732,0.00001174627,0.00001404644,0.0006173522,0.9966964,0.00008363301,0.00001900632,0.001592344],"study_design_scores_gemma":[0.000003122439,0.00005027312,0.01848916,0.000005003099,0.0000198613,0.0001434092,0.00002951261,0.02343248,0.9566567,0.0005586363,0.0005958838,0.00001607626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8573521,0.0005752858,0.1395053,0.00009204107,0.00001287238,0.00003772605,0.001249539,0.0004201754,0.0007548378],"genre_scores_gemma":[0.9185238,0.0007609174,0.07881141,0.0001267051,0.00001194683,0.0001136696,0.0009537977,0.0001117546,0.0005860144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006508665,"threshold_uncertainty_score":0.002994835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01283108502731632,"score_gpt":0.2306887246795233,"score_spread":0.217857639652207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}