{"id":"W2053503988","doi":"10.1242/dev.00474","title":"Tbx5 and Tbx4 trigger limb initiation through activation of the Wnt/Fgf signaling cascade","year":2003,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Biology; Fibroblast growth factor; Forelimb; Wnt signaling pathway; Limb development; Gastrulation; Cell biology; Psychological repression; Anatomy; Hindlimb; Morphogenesis; Gene; Genetics; Signal transduction; Gene expression; Embryo; Embryonic stem cell; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735881,0.00006941154,0.00006430522,0.00002111898,0.00008291413,0.00001109757,0.00005474287,0.00006797571,0.00001945112],"category_scores_gemma":[0.0001407995,0.00005330009,0.0000248563,0.00009608038,0.00003117937,0.000004941632,0.00005470134,0.00005823682,0.000003216229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002522825,"about_ca_system_score_gemma":0.0001699649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007053709,"about_ca_topic_score_gemma":0.00001283262,"domain_scores_codex":[0.9993765,0.00006779881,0.0001366057,0.0001468299,0.0001492757,0.0001229278],"domain_scores_gemma":[0.9997341,0.00002198832,0.00004026893,0.0001084231,0.00007164195,0.00002356307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003261303,0.00003674045,0.00316397,0.00003654996,0.00003857302,5.725502e-7,0.0005359373,0.00001107993,0.9895241,0.0001804288,0.0001592121,0.006280227],"study_design_scores_gemma":[0.0002125044,0.00003775429,0.01219434,0.0000143864,0.000003120295,0.000005134159,0.00005942679,0.000004400906,0.9566296,0.00006607021,0.03070494,0.00006832444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973664,0.0002359618,0.0005072482,0.00007282416,0.00004198358,0.0001840162,0.000001075124,0.000003066191,0.001587419],"genre_scores_gemma":[0.9984019,0.00003532698,0.0009253629,0.00008998687,0.00001997159,0.00001691447,0.00001293191,0.000008103991,0.000489546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03289449,"threshold_uncertainty_score":0.2173515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513537642921739,"score_gpt":0.2796738026283293,"score_spread":0.2545384261991119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}