{"id":"W2053551193","doi":"10.1021/jm060505l","title":"3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"NAEJA-RGM Pharmaceuticals (Canada)","funders":"","keywords":"DNA gyrase; Fastidious organism; Antibacterial activity; Chemistry; Topoisomerase IV; Antibacterial agent; In vivo; Multiple drug resistance; Topoisomerase inhibitor; Microbiology; Topoisomerase; Antibiotics; Bacteria; In vitro; Escherichia coli; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002954784,0.0002105722,0.0003749356,0.00003334448,0.00006270449,0.00002456172,0.0001758204,0.0002018684,0.00003829489],"category_scores_gemma":[0.0001262944,0.0001844693,0.0001001536,0.00008656608,0.0001094329,0.00001110714,0.00007377728,0.0001927357,3.546904e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003375197,"about_ca_system_score_gemma":0.0005708581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006656578,"about_ca_topic_score_gemma":0.000009020557,"domain_scores_codex":[0.9986446,0.00003465822,0.0005282025,0.0002228254,0.0003467081,0.0002229724],"domain_scores_gemma":[0.9986919,0.00001771487,0.0006572221,0.0001816631,0.0002418941,0.000209594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001757793,0.0001284551,0.0002566192,0.00009213268,0.00009139432,0.00004383979,0.00005151617,0.00000797315,0.9940327,0.000005400955,0.0005453308,0.002986859],"study_design_scores_gemma":[0.002470035,0.0006678684,0.001231235,0.0001690231,0.0001033413,0.000246292,0.0001615066,0.00002573594,0.9883857,0.00005383962,0.006312725,0.0001727014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978791,0.0005708006,0.0002926612,0.0002334339,0.0006572262,0.00007470845,0.00001367927,0.000003885608,0.000274493],"genre_scores_gemma":[0.9958014,0.0007088477,0.0006424193,0.00008556888,0.002432965,4.197749e-7,0.00002854234,0.00002357462,0.0002762695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005767394,"threshold_uncertainty_score":0.7522441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034475688832005,"score_gpt":0.254141438599465,"score_spread":0.2437966817111449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}