{"id":"W2053565628","doi":"10.1074/jbc.m114.606392","title":"Class IIa Histone Deacetylases Are Conserved Regulators of Circadian Function","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RIKEN; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Queen Mary University of London; Wellcome Trust; McGill University","keywords":"Histone deacetylase 5; HDAC4; Biology; Circadian clock; Cell biology; Acetylation; Circadian rhythm; Gene knockdown; Histone; Histone H4; Histone deacetylase; Genetics; Gene; Endocrinology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235529,0.0004997796,0.000276666,0.0002509771,0.0003590109,0.0005852356,0.0002593641,0.0002375619,0.001750447],"category_scores_gemma":[0.0001172514,0.0001394963,0.0002463249,0.0002650096,0.0002309736,0.0002323297,0.0002287626,0.0002702083,0.0009670431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004775198,"about_ca_system_score_gemma":0.0002357188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368603,"about_ca_topic_score_gemma":0.002338854,"domain_scores_codex":[0.9999065,0.000006990714,0.000006530769,0.00003441285,0.00001973194,0.00002565331],"domain_scores_gemma":[0.9999158,0.000004249197,0.00003643028,0.00000845273,0.00001469232,0.0000202779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002693546,0.00002241102,0.005819808,0.0002110647,0.00004586626,0.0002058865,0.00004956744,0.0002022267,0.9374385,0.002324556,0.001475784,0.051935],"study_design_scores_gemma":[0.00007810794,0.000395976,0.1176747,0.00007096836,0.0001315401,0.001891974,0.0001693124,0.001887732,0.6827403,0.00218786,0.1927228,0.0000488058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7488936,0.1473005,0.05504019,0.0008141909,0.000921434,0.0002667648,0.004969167,0.002436603,0.0393576],"genre_scores_gemma":[0.9581541,0.01804486,0.006994102,0.0002718374,0.0001373368,0.00004840791,0.002338718,0.00007943428,0.0139312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001750447,"threshold_uncertainty_score":0.005855799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03446817360457918,"score_gpt":0.2516144623492774,"score_spread":0.2171462887446982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}