{"id":"W2053580956","doi":"10.1016/j.febslet.2014.02.026","title":"The multifaceted von Hippel–Lindau tumour suppressor protein","year":2014,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Epigenome; Cancer research; Hypoxia-inducible factors; Ubiquitin; Biology; Epigenetics; Suppressor; Tumor suppressor gene; Loss function; Clear cell renal cell carcinoma; Renal cell carcinoma; Cancer; Carcinogenesis; Gene; Genetics; DNA methylation; Medicine; Internal medicine; Gene expression; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003888621,0.000543865,0.0009229996,0.00006015854,0.000221575,0.0001182151,0.000753486,0.000431387,0.00001797837],"category_scores_gemma":[0.0001905975,0.0003713749,0.0006966439,0.0001090664,0.0001633835,0.000003250294,0.000210992,0.000436704,0.0001268481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481459,"about_ca_system_score_gemma":0.0001675485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003243801,"about_ca_topic_score_gemma":0.00003309232,"domain_scores_codex":[0.997603,0.0003440805,0.0005200877,0.0006888793,0.0002449031,0.0005990558],"domain_scores_gemma":[0.9984263,0.00004044177,0.0003909213,0.000947587,0.00006089097,0.0001338371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004565692,0.00003305327,6.728787e-7,0.002889335,0.0003902338,0.000004012889,0.00003000374,0.000002926375,0.07104077,0.00003152921,0.1249795,0.8005523],"study_design_scores_gemma":[0.0003417394,0.00004221006,0.000003445723,0.0008454959,0.000276381,0.00002123796,0.000005170952,0.00000243507,0.002950497,0.000002373734,0.9950361,0.0004729035],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006994366,0.9945958,0.0001706431,0.0006002127,0.002281201,0.001373925,0.00009743941,0.00003108363,0.0001502748],"genre_scores_gemma":[0.00008219686,0.9888958,0.0001385531,0.0009253327,0.006032692,0.0005033123,0.0005018832,0.0001225255,0.002797725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8700566,"threshold_uncertainty_score":0.9998738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568282618236299,"score_gpt":0.2768982818362068,"score_spread":0.2612154556538439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}