{"id":"W2053591572","doi":"10.1089/ars.2009.2686","title":"The Unfolded Protein Response in Health and Disease","year":2009,"lang":"en","type":"editorial","venue":"Antioxidants and Redox Signaling","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Amgen Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Unfolded protein response; Endoplasmic reticulum; Cell biology; Biology; Context (archaeology); Protein folding; Cellular stress response; Transmembrane protein; Fight-or-flight response; Genetics; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006779081,0.0002700886,0.000268888,0.00005722692,0.0002937013,0.0001356053,0.0001484284,0.0002696019,0.000001390061],"category_scores_gemma":[0.00129321,0.0001912212,0.00007211777,0.00006486664,0.0001573831,0.000004620683,0.0001000494,0.0002652676,6.417335e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001444649,"about_ca_system_score_gemma":0.0007040521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005083388,"about_ca_topic_score_gemma":0.00001714631,"domain_scores_codex":[0.998158,0.0002951342,0.0003853141,0.0005285102,0.0002596558,0.0003733754],"domain_scores_gemma":[0.9988871,0.0001292715,0.0001996795,0.0003027196,0.00005902955,0.0004222499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02176605,0.00037451,0.001132637,0.001419755,0.0002200853,0.000405284,0.0002828459,0.00007388791,0.149945,0.0003208049,0.8012936,0.02276554],"study_design_scores_gemma":[0.002957653,0.001172485,0.001399494,0.002213065,0.00005054426,0.000007342074,0.0002933454,0.0001132432,0.002705614,0.001443946,0.9867318,0.00091149],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9088849,0.05466697,0.00003208339,0.001183057,0.03425799,0.0007398198,0.0001650716,0.00001729105,0.00005274749],"genre_scores_gemma":[0.8462527,0.02907768,0.0001577211,0.0003686338,0.121287,0.00008636662,0.0004133512,0.0000834547,0.002273135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1854382,"threshold_uncertainty_score":0.7797772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004370685923197675,"score_gpt":0.2546731623380276,"score_spread":0.2503024764148299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}