{"id":"W2053664689","doi":"10.1021/ol900972j","title":"Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the Fungus <i>Plectosphaerella cucumerina</i>","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Indoleamine 2,3-dioxygenase; Fungus; Chemistry; Stereochemistry; Microbiology; Biochemistry; Botany; Tryptophan; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007677827,0.0003687908,0.0001408049,0.000239212,0.0001896,0.0002666136,0.0001347796,0.0002024778,0.0005907386],"category_scores_gemma":[0.0001137153,0.00008917782,0.0001223818,0.0001772045,0.0001819505,0.00008544911,0.000097377,0.000381489,0.0002797588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475477,"about_ca_system_score_gemma":0.0003791203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006006217,"about_ca_topic_score_gemma":0.01272117,"domain_scores_codex":[0.9999355,0.000008443115,0.000005683271,0.0000177429,0.0000158967,0.00001670449],"domain_scores_gemma":[0.9998999,0.00001842892,0.00002743903,0.00001078665,0.00001231752,0.00003124865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000538871,0.00001273888,0.0001532392,0.0000164622,0.000002323922,0.00004713394,0.000005623139,0.00003420964,0.9988864,0.0000237316,0.00002244344,0.000741665],"study_design_scores_gemma":[0.00001600739,0.0001986666,0.003734765,0.00000628931,0.000009494763,0.0001994813,0.00001736618,0.0001413159,0.9936512,0.00002781629,0.001993621,0.000004019335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892862,0.002688546,0.002289637,0.00007916394,0.00003231219,0.00009098861,0.001566665,0.0001071518,0.003859306],"genre_scores_gemma":[0.9929129,0.001024838,0.003504335,0.00003505456,0.000008253163,0.00002443078,0.001182357,0.00001927066,0.001288484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006006217,"threshold_uncertainty_score":0.01194251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005006398234023705,"score_gpt":0.196342178874188,"score_spread":0.1913357806401643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}