{"id":"W2053664689","doi":"10.1021/ol900972j","title":"Plectosphaeroic Acids A, B, and C, Indoleamine 2,3-Dioxygenase Inhibitors Produced in Culture by a Marine Isolate of the Fungus <i>Plectosphaerella cucumerina</i>","year":2009,"lang":"en","type":"article","venue":"Organic Letters","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Indoleamine 2,3-dioxygenase; Fungus; Chemistry; Stereochemistry; Microbiology; Biochemistry; Botany; Tryptophan; Biology; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098877,0.0002777059,0.0002796199,0.00007333365,0.0001047875,0.0000403572,0.0004062134,0.00009203044,0.00006976235],"category_scores_gemma":[0.0002880396,0.0002054822,0.0000692309,0.001088636,0.0001739328,0.0001563311,0.0001471928,0.0003644128,0.00001034508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005063867,"about_ca_system_score_gemma":0.00003686911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004679109,"about_ca_topic_score_gemma":0.00005815081,"domain_scores_codex":[0.9982204,0.000128774,0.0003420529,0.0005679404,0.0002920078,0.0004487846],"domain_scores_gemma":[0.9992775,0.0000516586,0.0001529757,0.0004141187,0.00001551343,0.00008821621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006283241,0.0001205781,0.001923325,0.00002808175,0.000004256689,0.00001465759,0.0005150762,0.000002419552,0.9909139,0.00002314066,0.004860227,0.001531567],"study_design_scores_gemma":[0.001453358,0.0001431512,0.01239826,0.00003526059,0.000004503831,0.00003799576,0.00002957256,0.00001678758,0.9845006,0.00004836495,0.001092347,0.0002397737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932872,0.0003058033,0.00001068833,0.005533636,0.0001456939,0.0004868608,0.000009167769,0.00005683299,0.000164109],"genre_scores_gemma":[0.9895567,0.0001746047,0.00002825472,0.009975927,0.00004829298,0.000007193431,0.000002547598,0.00002933841,0.0001771842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01047493,"threshold_uncertainty_score":0.837932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005006398234023705,"score_gpt":0.196342178874188,"score_spread":0.1913357806401643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}