{"id":"W2053676841","doi":"10.1021/bi034862z","title":"Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and <i>p</i>CMB-Sensitive Intracellular Degradative Pathway","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University; University of Toronto; University Health Network","funders":"","keywords":"Endoplasmic reticulum; Secretion; Apolipoprotein B; Intracellular; Unfolded protein response; Cell biology; Protein degradation; Calnexin; Secretory protein; ER retention; Calcium in biology; Biology; Calreticulin; Molecular biology; Chemistry; Biochemistry; Mutant; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003236889,0.0004952776,0.0003592162,0.00004086207,0.0002689002,0.00007101592,0.0003280706,0.0005313673,0.000009356381],"category_scores_gemma":[0.0008913276,0.000410793,0.000185343,0.0001834808,0.0003429964,0.00005714128,0.0002131124,0.0002780608,0.000001705342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008264418,"about_ca_system_score_gemma":0.0003682253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001018999,"about_ca_topic_score_gemma":0.00001300829,"domain_scores_codex":[0.9973604,0.0001759568,0.0005646785,0.0009993102,0.0004114611,0.0004881622],"domain_scores_gemma":[0.9980522,0.00007507204,0.0005603182,0.0006744472,0.0003514109,0.0002865787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005008089,0.0002292533,0.0001776871,0.000348543,0.00006056564,0.00001017486,0.0001478747,0.0001561127,0.9977514,0.00003717296,0.00006399764,0.0005164629],"study_design_scores_gemma":[0.00173605,0.0004202017,0.0002150566,0.0009729938,0.00006583977,0.00003753788,0.0003099781,0.002087029,0.9933848,0.000163526,0.0001094709,0.0004975662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927641,0.002242494,0.00244724,0.0001996454,0.00007631064,0.001579247,0.000598522,0.00003501933,0.00005747135],"genre_scores_gemma":[0.9966357,0.0001478929,0.001042044,0.00005677825,0.0001734215,0.0002013938,0.001509338,0.00005716078,0.0001762867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004366596,"threshold_uncertainty_score":0.9998344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210008507921281,"score_gpt":0.2316169180720865,"score_spread":0.2195168329928736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}