{"id":"W2053676841","doi":"10.1021/bi034862z","title":"Overexpression of the Endoplasmic Reticulum 60 Protein ER-60 Downregulates ApoB100 Secretion by Inducing Its Intracellular Degradation via a Nonproteasomal Pathway:  Evidence for an ER-60-Mediated and <i>p</i>CMB-Sensitive Intracellular Degradative Pathway","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University; University of Toronto; University Health Network","funders":"","keywords":"Endoplasmic reticulum; Secretion; Apolipoprotein B; Intracellular; Unfolded protein response; Cell biology; Protein degradation; Calnexin; Secretory protein; ER retention; Calcium in biology; Biology; Calreticulin; Molecular biology; Chemistry; Biochemistry; Mutant; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515862,0.0003347831,0.0003660207,0.0001540843,0.00009876988,0.0003301027,0.0001520194,0.0002398775,0.0007787176],"category_scores_gemma":[0.00009414239,0.0001567762,0.0003123501,0.0001662476,0.0002836526,0.000190166,0.0001930605,0.0005536666,0.0004120448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672256,"about_ca_system_score_gemma":0.0001550215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003614527,"about_ca_topic_score_gemma":0.000368739,"domain_scores_codex":[0.999861,0.0000211753,0.00002409738,0.00003073027,0.00002543958,0.00003760529],"domain_scores_gemma":[0.9998872,0.00002091909,0.00002839932,0.00001939865,0.00001143971,0.00003268197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079519,0.00003750195,0.00004493278,0.00002360603,0.000003071603,0.00002074177,0.000007122916,0.00001468544,0.999339,0.00002593479,0.00001234423,0.0003629929],"study_design_scores_gemma":[0.00002875086,0.0003372498,0.002265289,0.000004712474,0.00002056253,0.00008518835,0.00002136872,0.0004999013,0.9956148,0.00001871761,0.001100484,0.000002998049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950371,0.001484888,0.002004818,0.0001380347,0.00004640724,0.00002765153,0.0001919228,0.00009125697,0.0009778267],"genre_scores_gemma":[0.9929333,0.001488232,0.002008616,0.00008011227,0.00001741907,0.00004472394,0.0005385823,0.00003838407,0.002850656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007787176,"threshold_uncertainty_score":0.002605021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210008507921281,"score_gpt":0.2316169180720865,"score_spread":0.2195168329928736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}