{"id":"W2053705560","doi":"10.2174/156720511794604561","title":"Transgenic Mice as a Model of Pre-Clinical Alzheimers Disease","year":2011,"lang":"en","type":"article","venue":"Current Alzheimer Research","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canadian Institutes of Health Research; Regione Autonoma della Sardegna","keywords":"Hippocampus; Genetically modified mouse; Alzheimer's disease; Neuroscience; Transgene; Pathology; Amyloid precursor protein; Amyloid (mycology); Insulin-degrading enzyme; Pathological; Disease; Medicine; Biology; Internal medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005171514,0.001467547,0.0008059415,0.001384488,0.0006264383,0.0007382956,0.001011068,0.001600412,0.004831001],"category_scores_gemma":[0.0002119197,0.0006448695,0.0005542255,0.0006006969,0.0005232787,0.0005907448,0.0005612933,0.002330534,0.002364899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004999702,"about_ca_system_score_gemma":0.0004144002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009695792,"about_ca_topic_score_gemma":0.001539053,"domain_scores_codex":[0.999406,0.00008478596,0.00007493946,0.0001830285,0.0001447758,0.000106467],"domain_scores_gemma":[0.9996114,0.00005180783,0.0001134047,0.0000536104,0.00004698243,0.0001228177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000714682,0.0005643661,0.0003464922,0.0001198271,0.0000243813,0.0005480885,0.0001485276,0.000138328,0.9922829,0.00125831,0.0006560677,0.003198058],"study_design_scores_gemma":[0.001292332,0.009447712,0.01604863,0.000299286,0.0004664596,0.009770306,0.0003576923,0.003222144,0.8431267,0.003793311,0.1120066,0.0001687946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.938732,0.007251924,0.02954038,0.001385603,0.0007441567,0.00118631,0.009347182,0.001941407,0.009871108],"genre_scores_gemma":[0.8492996,0.01400263,0.05847481,0.001185156,0.0003955955,0.003596692,0.0156128,0.0006926325,0.05674015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004831001,"threshold_uncertainty_score":0.01616126,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4530116163562123,"score_gpt":0.507734281308624,"score_spread":0.05472266495241168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}