{"id":"W2053713981","doi":"10.1021/ol050501v","title":"High-Yielding Intramolecular Direct Arylation Reactions with Aryl Chlorides","year":2005,"lang":"en","type":"article","venue":"Organic Letters","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Aryl; Halide; Intramolecular force; Catalysis; Carbene; Palladium; Ring (chemistry); Combinatorial chemistry; Organic chemistry; Medicinal chemistry; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004291048,0.001061823,0.0005220671,0.0004005622,0.0004286924,0.0004266278,0.0009061219,0.0005364216,0.003559379],"category_scores_gemma":[0.0003010325,0.0002642462,0.0002699938,0.0005199959,0.0002715637,0.0005244846,0.001061558,0.001033091,0.002771424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003928248,"about_ca_system_score_gemma":0.0004184914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068151,"about_ca_topic_score_gemma":0.00297774,"domain_scores_codex":[0.9994534,0.00005130383,0.00004526567,0.0001032496,0.0001551498,0.000191678],"domain_scores_gemma":[0.9998746,0.00001595601,0.00001798663,0.00002126595,0.00003032363,0.00003993854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758256,0.000149081,0.0002926024,0.0003757672,0.00004942278,0.0004037836,0.0002133422,0.0003067666,0.9777624,0.001647271,0.001745993,0.01687785],"study_design_scores_gemma":[0.00004792354,0.0003269737,0.0006752016,0.00001000692,0.00003744714,0.0003190343,0.00002260199,0.0003778871,0.9869718,0.0001038588,0.01108683,0.00002039339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8691015,0.007558968,0.04061731,0.000510178,0.0003612279,0.0003497122,0.001793507,0.001840083,0.07786742],"genre_scores_gemma":[0.9749313,0.003572607,0.008071014,0.0001217895,0.00005192447,0.00008882523,0.0009974416,0.0001283805,0.01203666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003559379,"threshold_uncertainty_score":0.01190734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005667214880528116,"score_gpt":0.2068133751515918,"score_spread":0.2011461602710637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}