{"id":"W2053714100","doi":"10.1074/jbc.m006082200","title":"Mapping of the ATP-binding Sites on Inositol 1,4,5-Trisphosphate Receptor Type 1 and Type 3 Homotetramers by Controlled Proteolysis and Photoaffinity Labeling","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Fonds Wetenschappelijk Onderzoek; Université de Sherbrooke; Thomas Jefferson University","keywords":"Proteolysis; Photoaffinity labeling; Inositol; Chemistry; Biochemistry; Receptor; Binding site; Stereochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003138533,0.0001259381,0.000271029,0.00001775035,0.00008414589,0.00001981605,0.0001149607,0.000187094,0.00004252974],"category_scores_gemma":[0.0007023338,0.00007706664,0.00008546918,0.0001651821,0.000119396,0.00000446681,0.00006354224,0.0001848172,3.84471e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227989,"about_ca_system_score_gemma":0.00003485265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002009035,"about_ca_topic_score_gemma":9.735706e-8,"domain_scores_codex":[0.9992145,0.00005715396,0.000326831,0.0001556447,0.0001142971,0.0001315976],"domain_scores_gemma":[0.9992016,0.00005040128,0.000381494,0.0001033449,0.0001857214,0.00007743001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007463177,0.00004518839,0.009084142,0.0000218251,0.00007099684,0.000002161647,0.00002211323,0.00000949113,0.9890723,9.797936e-7,0.0001508922,0.0007736481],"study_design_scores_gemma":[0.001330937,0.0002314201,0.0005370041,0.0000855387,0.00002005616,0.00003910982,0.0001196358,0.00003781865,0.9945138,0.00001564805,0.002965035,0.0001039944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996056,0.003433463,0.00003355815,0.000202698,0.00004255552,0.0001378347,0.000007610689,0.00000334616,0.00008298084],"genre_scores_gemma":[0.9980982,0.001182429,0.0004235895,0.00009027885,0.00008894711,0.000002010745,0.00001132605,0.000006236824,0.00009696446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008547137,"threshold_uncertainty_score":0.3142686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710370526023387,"score_gpt":0.2429424450212885,"score_spread":0.2258387397610546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}