{"id":"W2053768822","doi":"10.1080/03602530600569828","title":"Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)","year":2006,"lang":"en","type":"review","venue":"Drug Metabolism Reviews","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences","keywords":"Pregnane X receptor; Constitutive androstane receptor; Pregnane; Nuclear receptor; Pharmacology; Receptor; Chemistry; Biology; Transcription factor; Biochemistry; Gene; Stereochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003166166,0.001705385,0.006667398,0.0005667129,0.0003567412,0.00008029271,0.0007686057,0.0008695741,0.0003634236],"category_scores_gemma":[0.0007031079,0.00132381,0.0008067162,0.001019121,0.001548714,0.0002586036,0.0005260923,0.002184829,0.0002503712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007600075,"about_ca_system_score_gemma":0.0005270116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006646836,"about_ca_topic_score_gemma":0.000003829593,"domain_scores_codex":[0.9903572,0.003506236,0.00276004,0.00181145,0.0005038645,0.001061216],"domain_scores_gemma":[0.9951941,0.0007063162,0.002192111,0.0009449979,0.0003611615,0.0006013155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006808594,0.0002705873,0.000008924923,0.02195878,0.0006580732,0.00001425265,0.0006083628,0.000001347753,0.001503877,0.002538695,0.008517898,0.9638511],"study_design_scores_gemma":[0.001180694,0.00002863806,0.000006171249,0.00481959,0.006566331,0.0001323666,0.00003534411,0.00001312417,0.002883503,0.0001176331,0.9829817,0.00123494],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002810371,0.9829109,0.000002173999,0.0001346614,0.005437604,0.005571715,0.001301125,0.00008855102,0.00174286],"genre_scores_gemma":[0.0004652042,0.9927135,0.0007899256,0.0003365567,0.001061369,0.0005545276,0.0004455037,0.0001693911,0.00346404],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9744638,"threshold_uncertainty_score":0.9995692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07311730853590803,"score_gpt":0.4081307594694231,"score_spread":0.3350134509335151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}