{"id":"W2053777069","doi":"10.1016/j.bmc.2010.03.064","title":"Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Agonist; Stereochemistry; Moiety; Chemical synthesis; Receptor; Structure–activity relationship; Enzyme; Pharmacology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002462059,0.0003174416,0.0002599795,0.00002670262,0.0002548553,0.00002774904,0.0001892134,0.0004456455,0.0008148443],"category_scores_gemma":[0.0001507202,0.0002689702,0.00009506367,0.0002041917,0.0001776245,0.000007446389,0.0001011324,0.000455872,0.0000193772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004175506,"about_ca_system_score_gemma":0.0002933384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002931957,"about_ca_topic_score_gemma":0.00001333493,"domain_scores_codex":[0.9983285,0.00002455274,0.0002743049,0.0006346785,0.0003223454,0.0004156369],"domain_scores_gemma":[0.9989048,0.000008761195,0.0001640982,0.000425452,0.0002466147,0.0002502814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001755005,0.00008045253,0.00006090881,0.00002673959,0.00006539633,0.00001018665,0.00009496146,4.145227e-7,0.9947001,0.00001134205,0.004141297,0.0006326902],"study_design_scores_gemma":[0.0008118349,0.0004108588,0.0002064783,0.00006438477,0.00004317,0.0002141779,0.0001561933,0.000007405104,0.9842727,0.00002745657,0.01342831,0.0003569899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969087,0.0002404366,0.0003588886,0.0005474873,0.0003234198,0.000172848,0.00001888336,0.00005385524,0.001375458],"genre_scores_gemma":[0.994343,0.00004601863,0.001656665,0.000251038,0.001730998,0.0000176005,0.0003243609,0.00006038132,0.001569923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01042737,"threshold_uncertainty_score":0.9999763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00460061864108225,"score_gpt":0.2076819094055158,"score_spread":0.2030812907644336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}