{"id":"W2053789236","doi":"10.1063/1.4895530","title":"Effect of cosolvent on protein stability: A theoretical investigation","year":2014,"lang":"en","type":"article","venue":"The Journal of Chemical Physics","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Urea; Stoichiometry; Thermodynamics; Denaturation (fissile materials); Crystallography; Solvent; Solvation; Molecule; Folding (DSP implementation); Chemical physics; Physical chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005206394,0.0004909578,0.0004904014,0.00057295,0.0005220805,0.0005328402,0.0007297106,0.0008035968,0.001586506],"category_scores_gemma":[0.001984053,0.0002454322,0.0005825792,0.0004071811,0.0008709797,0.0008024058,0.0005478418,0.0004263909,0.0002219184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005622907,"about_ca_system_score_gemma":0.0005109208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001918436,"about_ca_topic_score_gemma":0.001255523,"domain_scores_codex":[0.9998319,0.00004804772,0.000006079976,0.00002471153,0.0000663588,0.00002287336],"domain_scores_gemma":[0.9994672,0.0003491591,0.00004795788,0.00004273899,0.00006977797,0.00002303457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001028166,0.0001255667,0.003140429,0.0002001017,0.00005187324,0.0004538882,0.0001100853,0.8669235,0.04590789,0.06897137,0.0002503418,0.01376221],"study_design_scores_gemma":[0.000003634,0.00002653736,0.0002303637,0.00000343888,0.000004350395,0.00001779518,0.00000522402,0.9948555,0.002458289,0.002222624,0.0001687746,0.000003410024],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7825466,0.001176366,0.2060472,0.0004593731,0.00004244086,0.00007481002,0.0001005667,0.0001936795,0.009358997],"genre_scores_gemma":[0.9739777,0.0007924606,0.02383093,0.00006062011,0.00002487346,0.00009739756,0.0000597949,0.0001018672,0.00105432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918436,"threshold_uncertainty_score":0.005307376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004087941573575839,"score_gpt":0.2234682763130537,"score_spread":0.2193803347394779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}