{"id":"W2053810311","doi":"10.1016/j.bmc.2008.06.044","title":"Synthesis of stable and selective inhibitors of human galectins-1 and -3","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University; Université Laval; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Sonogashira coupling; Cycloaddition; Alkyne; Galectin; Azide; Click chemistry; Galactosides; Stereochemistry; Combinatorial chemistry; Organic chemistry; Catalysis; Palladium; Glycoside; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002073444,0.0005837848,0.0003456756,0.0002149275,0.0001542501,0.0003397473,0.0005616018,0.0002888517,0.002141244],"category_scores_gemma":[0.0001785653,0.0002550225,0.0003504483,0.0002073911,0.0001705014,0.0002767436,0.0002524389,0.0007602029,0.000657081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005317618,"about_ca_system_score_gemma":0.0003894674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005402829,"about_ca_topic_score_gemma":0.001057488,"domain_scores_codex":[0.9998832,0.00001195457,0.000008605529,0.00002052591,0.00002933945,0.00004640855],"domain_scores_gemma":[0.9999278,0.00001174486,0.00002324297,0.000008533292,0.00001084874,0.00001792447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000319323,0.0001506765,0.0001155038,0.0001996036,0.0000539091,0.0001863097,0.00005028495,0.001801661,0.9769185,0.001808246,0.001153404,0.0172425],"study_design_scores_gemma":[0.0001140892,0.0004178455,0.0003323605,0.000008231244,0.00003637671,0.0002936441,0.000009022647,0.001622251,0.9819156,0.0002072636,0.01502915,0.0000141614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8365939,0.02231154,0.1094902,0.0009186621,0.0006641696,0.0009120603,0.003928443,0.001271969,0.02390897],"genre_scores_gemma":[0.9669082,0.007144708,0.01430546,0.0002999196,0.00004643852,0.0001985765,0.001923842,0.00007927186,0.009093605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002141244,"threshold_uncertainty_score":0.007163167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009211295835201522,"score_gpt":0.2149878355031957,"score_spread":0.2057765396679942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}