{"id":"W2053822674","doi":"10.1371/journal.pone.0038661","title":"Country, Sex, EDSS Change and Therapy Choice Independently Predict Treatment Discontinuation in Multiple Sclerosis and Clinically Isolated Syndrome","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Cégep de Lévis; Clinique Neuro-Outaouais","funders":"National Health and Medical Research Council; EMD Serono; Monash University; Eisai; Motor Neurone Disease Association; Fleni; Multiple Sclerosis Society; Medical Research Council; Biogen; Sanofi; Associazione Italiana Sclerosi Multipla; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Discontinuation; Medicine; Glatiramer acetate; Multiple sclerosis; Clinically isolated syndrome; Expanded Disability Status Scale; Internal medicine; Demographics; Natalizumab; Pediatrics; Immunology; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155651,0.0003271312,0.0004791374,0.0006335893,0.0004473109,0.0008372563,0.0003277649,0.0005162524,0.002461803],"category_scores_gemma":[0.00411549,0.0002460845,0.0007477725,0.0008178194,0.0002392556,0.0003562846,0.0004607638,0.0006633065,0.0003180247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403858,"about_ca_system_score_gemma":0.0004317583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003003466,"about_ca_topic_score_gemma":0.00298043,"domain_scores_codex":[0.9994011,0.0002296817,0.00007696876,0.0001104145,0.00008451155,0.0000974029],"domain_scores_gemma":[0.9949282,0.001066005,0.002936522,0.0002274205,0.0002867176,0.0005551229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001047869,0.0000119265,0.9994221,0.000002835493,0.00002354625,0.00001818996,0.00001124469,0.00001895037,0.00002777834,0.000001516937,0.00001776317,0.0003395449],"study_design_scores_gemma":[0.000008281287,0.0001106719,0.9993253,0.00000605277,0.00002382191,0.000206424,0.00005909658,0.0001681971,0.00002359265,0.000006538317,0.00006003775,0.000001943949],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993605,0.0002344345,0.00003306572,0.00002904709,0.000004197448,0.000003437413,0.0001829253,0.00000222026,0.0001502765],"genre_scores_gemma":[0.9995757,0.00005851266,0.00004106665,0.00001308163,0.000008404671,0.000003235519,0.0002283763,0.000001631304,0.00006990317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003003466,"threshold_uncertainty_score":0.008235514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2614884034424451,"score_gpt":0.3264083916161863,"score_spread":0.06491998817374123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}