{"id":"W2053822674","doi":"10.1371/journal.pone.0038661","title":"Country, Sex, EDSS Change and Therapy Choice Independently Predict Treatment Discontinuation in Multiple Sclerosis and Clinically Isolated Syndrome","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Cégep de Lévis; Clinique Neuro-Outaouais","funders":"National Health and Medical Research Council; EMD Serono; Monash University; Eisai; Motor Neurone Disease Association; Fleni; Multiple Sclerosis Society; Medical Research Council; Biogen; Sanofi; Associazione Italiana Sclerosi Multipla; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Discontinuation; Medicine; Glatiramer acetate; Multiple sclerosis; Clinically isolated syndrome; Expanded Disability Status Scale; Internal medicine; Demographics; Natalizumab; Pediatrics; Immunology; Demography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004770026,0.0002158444,0.0005489047,0.0001447572,0.0001034645,0.00003503045,0.00005414931,0.0001336044,0.00004552818],"category_scores_gemma":[0.0004062506,0.0001679259,0.00003336269,0.00015192,0.0001398784,0.0002924193,0.00008775557,0.0002088227,0.000009792849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001064087,"about_ca_system_score_gemma":0.0000202533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008437138,"about_ca_topic_score_gemma":0.0003644896,"domain_scores_codex":[0.9982491,0.0001039126,0.0003741145,0.000333209,0.0004936559,0.0004460138],"domain_scores_gemma":[0.9988676,0.0004525716,0.0000973302,0.0002425322,0.00007469647,0.0002652183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000521662,0.003586867,0.9554745,0.00005589098,0.0004744141,0.000004665578,0.001608802,5.692106e-8,0.01202155,0.000001594528,0.000007132451,0.02624286],"study_design_scores_gemma":[0.00752817,0.0022525,0.9870525,0.0004993532,0.0001034556,0.000005007157,0.0001448486,0.001265139,0.0009145847,0.000001815973,0.00008467754,0.0001479244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931262,0.00411285,0.000003219666,0.0006018382,0.00002765517,0.001912409,0.00005713482,0.00005727453,0.000101468],"genre_scores_gemma":[0.9724609,0.0262556,0.000275802,0.0001449092,0.000193568,0.000416255,0.00005478413,0.00003106788,0.0001670757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03157802,"threshold_uncertainty_score":0.6847821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2614884034424451,"score_gpt":0.3264083916161863,"score_spread":0.06491998817374123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}