{"id":"W2053832323","doi":"10.1371/journal.pone.0085737","title":"Syndecan-1 (CD138) Modulates Triple-Negative Breast Cancer Stem Cell Properties via Regulation of LRP-6 and IL-6-Mediated STAT3 Signaling","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":117,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutscher Akademischer Austauschdienst; Stem Cell Network","keywords":"Syndecan 1; CD44; Cancer stem cell; Biology; Population; Cancer research; Side population; Stem cell; Gene knockdown; Cell biology; Molecular biology; Cell; Apoptosis; Biochemistry; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208628,0.0001729515,0.0002484618,0.00007938914,0.00007903444,0.00003497827,0.0001368074,0.0001367846,0.0001037947],"category_scores_gemma":[0.00002569547,0.0001444633,0.00003881203,0.0001398265,0.0002076749,0.00001955885,0.00009974446,0.0001124993,0.000008175967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002858295,"about_ca_system_score_gemma":0.0000947777,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409995,"about_ca_topic_score_gemma":0.0000788645,"domain_scores_codex":[0.9987056,0.00008613853,0.0002696868,0.0003407901,0.0003016776,0.0002960987],"domain_scores_gemma":[0.9990678,0.00002096953,0.0001263739,0.0002369655,0.0004272472,0.0001206888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001852374,0.0002659167,0.002953698,0.0002866125,0.0001711082,6.835415e-7,0.0001621638,0.00006695426,0.9938903,0.000002511816,0.00005423667,0.001960571],"study_design_scores_gemma":[0.000738947,0.0002669505,0.009836458,0.0001562171,0.00003780723,0.000002382453,0.0001491908,0.00559829,0.9829396,0.00006906945,0.00001475613,0.0001903348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974461,0.001022127,0.0001381885,0.0002582447,0.00001598747,0.0008213513,0.0001932781,0.00001508125,0.00008960579],"genre_scores_gemma":[0.9972907,0.0003920353,0.0004635225,0.00003214617,0.00008154597,0.0002078219,0.00006659591,0.00002927861,0.001436387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01095071,"threshold_uncertainty_score":0.5891042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0260998813989078,"score_gpt":0.2194657982570909,"score_spread":0.1933659168581832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}