{"id":"W2053856666","doi":"10.4161/epi.1.3.3392","title":"Evaluation of a Quantitative DNA Methylation Analysis Technique using Methylation-Sensitive/Dependent Restriction Enzymes and Real-Time PCR","year":2006,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"","keywords":"DNA methylation; Sodium bisulfite; Biology; Bisulfite sequencing; Bisulfite; Methylation; Illumina Methylation Assay; DNA; Restriction enzyme; genomic DNA; Computational biology; Methylated DNA immunoprecipitation; Epigenetics; Molecular biology; Gene; Genetics; Gene expression; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002203048,0.0002015286,0.000283369,0.0003613299,0.0001195998,0.00002902492,0.00007215888,0.0002450857,0.00001471333],"category_scores_gemma":[0.0002781932,0.0002183968,0.0001238573,0.0005811183,0.00009008477,0.00001150316,0.00005595443,0.00006436019,0.000001400955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006899719,"about_ca_system_score_gemma":0.0001326674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006002108,"about_ca_topic_score_gemma":0.0002126037,"domain_scores_codex":[0.9975293,0.0006818056,0.0005464199,0.0004447582,0.0006104147,0.000187257],"domain_scores_gemma":[0.9980621,0.00008841456,0.0004383966,0.0003333348,0.001026067,0.00005164988],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002897646,0.00005311071,0.004136377,0.000008833751,0.0002324491,4.31091e-7,0.00005645773,0.04417562,0.9495189,0.0003213915,0.000004690673,0.001462812],"study_design_scores_gemma":[0.0003292388,0.0002080012,0.06416956,0.000009180468,0.001255109,9.218938e-7,0.00005796985,0.03356544,0.8976625,0.002491449,0.00003994838,0.0002106808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8471829,0.002235927,0.1492272,0.00001524925,0.0000482887,0.0004826433,0.00004172039,0.00001263129,0.0007534573],"genre_scores_gemma":[0.9732178,0.0007384772,0.02546008,0.000002829987,0.00009751676,0.00002642084,0.000371538,0.00002604941,0.00005926081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1260349,"threshold_uncertainty_score":0.8905965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03193866645925032,"score_gpt":0.320960727822867,"score_spread":0.2890220613636167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}