{"id":"W2053867184","doi":"10.1023/b:pham.0000041459.63362.6f","title":"Assessment of the Potential Skin Irritation of Lysine-Derivative Anionic Surfactants Using Mouse Fibroblasts and Human Keratinocytes as An Alternative to Animal Testing","year":2004,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":57,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institute of Steel Construction","keywords":"Sodium dodecyl sulfate; Chemistry; Counterion; Keratinocyte; Cytotoxicity; In vivo; Pulmonary surfactant; Irritation; Cationic polymerization; Sodium; Chromatography; In vitro; Biochemistry; Organic chemistry; Ion; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008813047,0.0006245638,0.0002399041,0.0002752592,0.0002611505,0.0002828379,0.0002410116,0.0006382585,0.001384831],"category_scores_gemma":[0.0003968609,0.0001648805,0.0005081231,0.0002623498,0.0003013854,0.0003251524,0.0002546056,0.000490706,0.0002532112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710369,"about_ca_system_score_gemma":0.0002475832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033935,"about_ca_topic_score_gemma":0.001288295,"domain_scores_codex":[0.9994903,0.0002018925,0.0000584806,0.0000670417,0.0001223739,0.00005986281],"domain_scores_gemma":[0.9994802,0.0002354981,0.00006290345,0.00008155619,0.0001128778,0.00002698505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009310841,0.00003585995,0.0001566739,0.00002243705,0.000003527486,0.00004633917,0.00002273184,0.000030848,0.999184,0.00002337442,0.00000568354,0.0003754028],"study_design_scores_gemma":[0.000003369157,0.000679598,0.0009720473,0.000001998037,0.00001416275,0.00008954108,0.00004221472,0.0001894612,0.9977739,0.00001193477,0.0002192085,0.000002565386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986675,0.001604097,0.00903791,0.00006576189,0.00005879187,0.0001354436,0.0002200539,0.00003548105,0.002167461],"genre_scores_gemma":[0.989759,0.001316879,0.00586585,0.00004634502,0.00001178646,0.00009828284,0.0002750269,0.00001140305,0.00261542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384831,"threshold_uncertainty_score":0.004660785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.338798203329262,"score_gpt":0.5854334552730868,"score_spread":0.2466352519438248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}