{"id":"W2053880711","doi":"10.1016/j.celrep.2013.06.022","title":"Polyester Modification of the Mammalian TRPM8 Channel Protein: Implications for Structure and Function","year":2013,"lang":"en","type":"article","venue":"Cell Reports","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; National Institutes of Health; National Institute of Neurological Disorders and Stroke; American Heart Association","keywords":"TRPM8; Chemistry; Chemical modification; Menthol; Linker; Ion channel; Biochemistry; Mutagenesis; Biophysics; Function (biology); Transient receptor potential channel; Serine; Enzyme; Organic chemistry; Cell biology; Biology; Mutant; TRPV1; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004762408,0.00007032065,0.00006778796,0.00002740366,0.0001464815,0.00002560238,0.0000584636,0.00005944103,0.00002831829],"category_scores_gemma":[0.00005279709,0.00004408848,0.0000406689,0.00009626761,0.00006108052,0.00009891233,0.00002457854,0.00004777142,0.000001362303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008701883,"about_ca_system_score_gemma":0.00001930751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000017214,"about_ca_topic_score_gemma":0.000001189602,"domain_scores_codex":[0.9993733,0.00001970563,0.0001946549,0.0002280004,0.00007654079,0.0001077703],"domain_scores_gemma":[0.9994496,0.00001729788,0.0002356772,0.0001976911,0.00006233723,0.00003746322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000002677782,0.00001647451,0.0001615447,0.00002973638,6.671148e-7,8.832795e-8,0.0001001483,0.00002301993,0.9977046,0.0002502174,0.0005295961,0.001181293],"study_design_scores_gemma":[0.00006737669,0.00002946926,0.009378715,0.000007032555,0.000006823796,0.00002380033,0.00002751366,0.0001577305,0.9810524,0.00793238,0.001257486,0.0000593011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954723,0.00002147882,0.0009997201,0.001377257,0.00047271,0.00123037,0.000009565087,0.00001694667,0.0003996991],"genre_scores_gemma":[0.9964543,0.000002783253,0.00004396211,0.00009679768,0.00007356756,0.0001605906,0.000003781972,0.00001038398,0.003153856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01665216,"threshold_uncertainty_score":0.1797876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02832141983921819,"score_gpt":0.2410636557934025,"score_spread":0.2127422359541843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}