{"id":"W2053902344","doi":"10.1158/1535-7163.targ-13-c70","title":"Abstract C70: A phase 2 study of intravenous administration of REOLYSIN® (reovirus type 3 dearing) in combination with paclitaxel (P) and carboplatin (C) in patients with squamous cell carcinoma of the lung.","year":2013,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Medicine; Carboplatin; Oncolytic virus; Internal medicine; Chemotherapy; Regimen; Clinical endpoint; Oncology; Gastroenterology; Phases of clinical research; Rash; Paclitaxel; Clinical trial; Cancer; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00119887,0.001738153,0.001651119,0.0006437745,0.0004594059,0.001052418,0.0008894518,0.001693718,0.00360286],"category_scores_gemma":[0.0005835921,0.0006149134,0.001181033,0.00045921,0.0009073932,0.0006974629,0.0002926493,0.003035206,0.0007997238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077933,"about_ca_system_score_gemma":0.002153659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002088667,"about_ca_topic_score_gemma":0.003761629,"domain_scores_codex":[0.9996112,0.0001604036,0.00001635251,0.00006698666,0.00004333133,0.0001017563],"domain_scores_gemma":[0.9994517,0.00008344329,0.0000892883,0.00003933692,0.00004294072,0.0002934222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6253759,0.1851751,0.002736717,0.00119418,0.001268379,0.0003863836,0.000345238,0.002622807,0.09950012,0.0003773801,0.003008635,0.0780092],"study_design_scores_gemma":[0.3402032,0.6466863,0.004458241,0.00002519773,0.0003038237,0.000185518,0.00004617525,0.000908145,0.005740597,0.00008567151,0.001327054,0.00003017074],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932117,0.001090668,0.0004822127,0.0002432013,0.00009242471,0.002819839,0.0005704508,0.000105473,0.001383901],"genre_scores_gemma":[0.991863,0.001089079,0.00107251,0.0005385343,0.0001417467,0.001839398,0.0009829679,0.00002871971,0.002443983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00360286,"threshold_uncertainty_score":0.01205277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092082922319129,"score_gpt":0.2704467142879798,"score_spread":0.2595258850647885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}