{"id":"W2053941125","doi":"10.1074/jbc.m109.033670","title":"pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Internalization; Endosome; NOD1; Endocytosis; Cell biology; NOD2; Peptidoglycan; Endocytic cycle; Cytosol; Biology; Signal transduction; Muramyl dipeptide; Chemistry; Biochemistry; Intracellular; Receptor; Innate immune system; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001298642,0.0001948378,0.00025166,0.0001274779,0.0001205863,0.000367789,0.00009985478,0.0002866236,0.000772483],"category_scores_gemma":[0.000127923,0.0001075475,0.0003495822,0.00009617832,0.0001788248,0.0002773791,0.0004289906,0.0002878892,0.0002944216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003253688,"about_ca_system_score_gemma":0.0001500686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111563,"about_ca_topic_score_gemma":0.0004649506,"domain_scores_codex":[0.9998246,0.000033848,0.00001486275,0.00003720473,0.00004011454,0.00004932117],"domain_scores_gemma":[0.9999408,0.000009565894,0.00001626723,0.000008130012,0.00001145495,0.00001384927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009021077,0.000004537746,0.0003744366,0.00002219255,0.000002764003,0.00007274088,0.000006407822,0.00003228033,0.9989854,0.00002862009,0.000007761269,0.0003726582],"study_design_scores_gemma":[0.00002223896,0.0001690344,0.02367963,0.000009291663,0.00001482696,0.0009193178,0.00006452129,0.001560947,0.9718753,0.00006530414,0.001611075,0.000008597466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995974,0.001132184,0.001607094,0.00006006493,0.00001215871,0.00001231929,0.0001679098,0.00002801295,0.00100639],"genre_scores_gemma":[0.9961274,0.0005235178,0.001776822,0.00005533169,0.000006196297,0.00001832769,0.0003317718,0.000009567952,0.00115102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000772483,"threshold_uncertainty_score":0.002584219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273180685745421,"score_gpt":0.2233235820738403,"score_spread":0.2105917752163861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}