{"id":"W2053941125","doi":"10.1074/jbc.m109.033670","title":"pH-dependent Internalization of Muramyl Peptides from Early Endosomes Enables Nod1 and Nod2 Signaling","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":211,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canada Research Chairs","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Internalization; Endosome; NOD1; Endocytosis; Cell biology; NOD2; Peptidoglycan; Endocytic cycle; Cytosol; Biology; Signal transduction; Muramyl dipeptide; Chemistry; Biochemistry; Intracellular; Receptor; Innate immune system; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002422769,0.0001136563,0.0002979463,0.0000363695,0.00004390981,0.00001575529,0.0001547938,0.0002440654,0.0002633624],"category_scores_gemma":[0.0002247707,0.00007782759,0.0001003198,0.00004187397,0.00009589952,0.000103158,0.00003134805,0.0002309463,0.000005686224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002077312,"about_ca_system_score_gemma":0.00002377318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001250053,"about_ca_topic_score_gemma":1.341707e-7,"domain_scores_codex":[0.9991133,0.00008519377,0.000516584,0.0001083667,0.0000445359,0.0001319859],"domain_scores_gemma":[0.9991435,0.0001446866,0.0004879864,0.00008060476,0.0001225173,0.0000206847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005228761,0.00006235039,0.003777415,0.00001006599,0.00008607308,0.000009164859,0.0001603123,0.000005069237,0.9916873,0.00001875497,0.0000375506,0.00362308],"study_design_scores_gemma":[0.0007353195,0.0002540068,0.009990838,0.0001299884,0.00002801704,0.0001121364,0.0001745291,0.00000219889,0.9873627,0.0006777478,0.0004487839,0.00008368979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934942,0.005614683,0.0004730913,0.0001088198,0.00007741317,0.0000333236,0.000006135448,0.000009253366,0.0001831481],"genre_scores_gemma":[0.9990523,0.0005692915,0.0001089401,0.00005089877,0.00007790353,4.792313e-7,0.00001869097,0.000003200614,0.0001182347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006213423,"threshold_uncertainty_score":0.3173717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273180685745421,"score_gpt":0.2233235820738403,"score_spread":0.2105917752163861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}