{"id":"W2053941511","doi":"10.1038/nm.2315","title":"Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Neuregulin 1; ERBB4; NMDA receptor; ErbB; Long-term potentiation; Neuroscience; Hippocampal formation; Proto-oncogene tyrosine-protein kinase Src; Hippocampus; Neuregulin; Schaffer collateral; Signal transduction; Glutamate receptor; Receptor tyrosine kinase; Receptor; Medicine; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554804,0.0003347359,0.0002528577,0.0003156749,0.000196895,0.0002933656,0.0002634731,0.0002286169,0.002220009],"category_scores_gemma":[0.0001775981,0.0001696372,0.0002419146,0.0001640911,0.0002532974,0.0001702968,0.0002225733,0.000656538,0.0004600328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004220864,"about_ca_system_score_gemma":0.000331569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001564148,"about_ca_topic_score_gemma":0.003313169,"domain_scores_codex":[0.9997831,0.00004071085,0.00002246055,0.00002961661,0.00004999341,0.00007419432],"domain_scores_gemma":[0.9998736,0.00001875393,0.00003372914,0.00002638191,0.00001237744,0.00003510655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002058529,0.0000263097,0.0001209143,0.00000997706,0.000006609242,0.00004043304,0.000005926057,0.00004379294,0.9987577,0.0001102779,0.00004130186,0.0006308184],"study_design_scores_gemma":[0.000044856,0.0001930723,0.006345834,0.000003585782,0.00002287204,0.0002748224,0.00005823206,0.000804962,0.9904136,0.00007937761,0.001754188,0.000004578834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997358,0.0004352354,0.0006070864,0.0001206148,0.00002717305,0.000007319389,0.0002258535,0.00004205331,0.001176608],"genre_scores_gemma":[0.9954256,0.0003308731,0.0005621368,0.00004300037,0.000006332322,0.00001340348,0.0002885701,0.0000160583,0.003314062],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002220009,"threshold_uncertainty_score":0.007426679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330076220221212,"score_gpt":0.2395064548509228,"score_spread":0.2262056926487107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}