{"id":"W2053941511","doi":"10.1038/nm.2315","title":"Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors","year":2011,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":169,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Neuregulin 1; ERBB4; NMDA receptor; ErbB; Long-term potentiation; Neuroscience; Hippocampal formation; Proto-oncogene tyrosine-protein kinase Src; Hippocampus; Neuregulin; Schaffer collateral; Signal transduction; Glutamate receptor; Receptor tyrosine kinase; Receptor; Medicine; Cell biology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004259547,0.0002045107,0.0002819409,0.00006799868,0.00005448677,0.000003699434,0.0002423794,0.0005074631,0.001237202],"category_scores_gemma":[0.000343466,0.0001557602,0.00009444932,0.0001574681,0.0001599196,0.000006647497,0.00006707573,0.000294785,0.000003748283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001001078,"about_ca_system_score_gemma":0.00005543861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004607899,"about_ca_topic_score_gemma":0.0000379915,"domain_scores_codex":[0.9986358,0.00009942514,0.0003582363,0.000415634,0.0002776552,0.0002132535],"domain_scores_gemma":[0.9989898,0.00002231954,0.0001814024,0.0004751138,0.0002274888,0.0001039113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003366341,0.00005881345,0.001178039,0.00004310618,0.00003444349,0.000001106784,0.0002164881,0.000005722131,0.9895948,0.0005946961,0.002632165,0.00530398],"study_design_scores_gemma":[0.0008345176,0.0006232264,0.003532508,0.00006445913,0.00002459296,0.000004378684,0.0001224765,0.00002064743,0.9829341,0.000791622,0.01089004,0.0001574259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933376,0.002114852,0.001390498,0.0001693665,0.001153713,0.0002343104,0.00001318161,0.0000244736,0.001562032],"genre_scores_gemma":[0.9957123,0.00009436357,0.002592049,0.000145091,0.0008668441,0.000007338228,0.0001874812,0.00002564663,0.0003689135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008257873,"threshold_uncertainty_score":0.9996758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330076220221212,"score_gpt":0.2395064548509228,"score_spread":0.2262056926487107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}