{"id":"W2053960137","doi":"10.1158/1535-7163.targ-11-a50","title":"Abstract A50: Biomarker analysis of PTEN, targeted oncogenic mutations, and HPV in a phase II trial of the irreversible oral pan-human EGF receptor (HER) inhibitor dacomitinib (D) (PF-299804) as first-line treatment in recurrent and/or metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN).","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Pfizer (Canada); London Health Sciences Centre; Sunnybrook Health Science Centre; Juravinski Cancer Centre; Ontario Clinical Oncology Group; BC Cancer Agency; Princess Margaret Cancer Centre; Ottawa Hospital; University Health Network","funders":"","keywords":"PTEN; Neuroblastoma RAS viral oncogene homolog; Medicine; Biomarker; Cancer; Genotyping; Exact test; Mutation; Internal medicine; Oncology; Genotype; Cancer research; KRAS; Gene; Biology; Genetics; Apoptosis; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848909,0.0002576823,0.0007393706,0.0002467365,0.00006839421,0.000007214534,0.00008940791,0.00007807721,0.0001488773],"category_scores_gemma":[0.00001825424,0.0001546482,0.000238395,0.0007392176,0.0002004062,0.00003405935,0.0000616263,0.0001135292,1.348973e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002283691,"about_ca_system_score_gemma":0.0002525698,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007151378,"about_ca_topic_score_gemma":0.008230504,"domain_scores_codex":[0.9983832,0.0001503224,0.0006762845,0.0003271995,0.000259882,0.0002031155],"domain_scores_gemma":[0.9989722,0.00009900432,0.0003974044,0.0003785846,0.00008290241,0.00006990839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07244655,0.05654855,0.4406296,0.001442022,0.01033951,0.0001881904,0.03328276,0.0001930977,0.1431878,0.00007523176,0.00009443446,0.2415722],"study_design_scores_gemma":[0.1600817,0.01530115,0.4354942,0.0004223468,0.01215089,0.00000787403,0.001149668,0.0009765623,0.3732013,0.0001160055,0.0006910394,0.0004072475],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857694,0.01190319,0.000003331394,0.0003746986,0.00009946441,0.00157874,0.0002367614,0.000004166114,0.00003025469],"genre_scores_gemma":[0.9978824,0.001549462,0.0001336477,0.0001007142,0.00001115018,0.0002340551,0.00003721537,0.00002354196,0.00002785191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.241165,"threshold_uncertainty_score":0.9994601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06901843089128866,"score_gpt":0.3468851743945893,"score_spread":0.2778667435033007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}