{"id":"W2053960742","doi":"10.1016/j.jconrel.2004.04.013","title":"Oral delivery of macromolecules using intestinal patches: applications for insulin delivery","year":2004,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":128,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"McGill University; American Diabetes Association","keywords":"Insulin; Enteral administration; Gastrointestinal tract; Pharmacology; In vivo; Drug delivery; Chemistry; Medicine; Hypoglycemia; Intestinal mucosa; Internal medicine; Biology; Parenteral nutrition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002492993,0.0003405624,0.0004292641,0.0001798091,0.0001882734,0.0005843566,0.0002975162,0.0005274643,0.001366776],"category_scores_gemma":[0.0002036255,0.000177169,0.0003819895,0.0001848101,0.0002407087,0.0006221442,0.0002791191,0.0006375007,0.0003511762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001832376,"about_ca_system_score_gemma":0.0001144695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002957825,"about_ca_topic_score_gemma":0.000284665,"domain_scores_codex":[0.9999242,0.00001366984,0.000003674194,0.00002188579,0.00001596584,0.00002054522],"domain_scores_gemma":[0.9999106,0.00002511368,0.00002376309,0.00001068108,0.00001189458,0.00001792005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004362195,0.00007891167,0.0001811495,0.0002343665,0.000008273244,0.0001702758,0.00003977927,0.00005496873,0.9781908,0.0002161735,0.00009849764,0.02029061],"study_design_scores_gemma":[0.00006952183,0.001789499,0.001906427,0.00001567213,0.00007711109,0.000742186,0.0000488163,0.0007526292,0.9879295,0.00006072969,0.006599437,0.00000841323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9410056,0.02931106,0.02300296,0.0006079712,0.0002337029,0.000146964,0.00009254831,0.0003084055,0.00529077],"genre_scores_gemma":[0.9709111,0.01132789,0.01267347,0.0001465356,0.0001015016,0.00003823246,0.00006524743,0.00006683552,0.004669152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366776,"threshold_uncertainty_score":0.004572272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08209038542470337,"score_gpt":0.4071785321747983,"score_spread":0.325088146750095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}