{"id":"W2053963291","doi":"10.1016/j.jsbmb.2007.04.004","title":"Selective conversion by microglia of dehydroepiandrosterone to 5-androstenediol—A steroid with inherent estrogenic properties","year":2007,"lang":"en","type":"article","venue":"The Journal of Steroid Biochemistry and Molecular Biology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Institute of Neurological Disorders and Stroke; U.S. Public Health Service; National Institutes of Health","keywords":"Dehydroepiandrosterone; Androstenediol; Estrone; Microglia; Estrogen; Neuroactive steroid; Testosterone (patch); Neuroprotection; Steroid; Endocrinology; Internal medicine; Androstenedione; Neuroinflammation; Chemistry; Aromatase; Biology; Medicine; Hormone; Androgen; Inflammation; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857537,0.0003779974,0.0002706796,0.0002636025,0.0002857445,0.0004354736,0.0001830961,0.0002561866,0.001016298],"category_scores_gemma":[0.0001430329,0.0001650075,0.0003822267,0.0001523462,0.0002227408,0.0002436718,0.0002336069,0.0003546459,0.0004046197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003214939,"about_ca_system_score_gemma":0.0003215944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007847329,"about_ca_topic_score_gemma":0.00182212,"domain_scores_codex":[0.9998228,0.00002656846,0.000008161757,0.00002418445,0.00003342337,0.00008504949],"domain_scores_gemma":[0.9999058,0.00001187256,0.00001583872,0.00002097932,0.00001690443,0.00002848617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002401514,0.00001460855,0.0002459876,0.00002985919,0.000008972385,0.0001643692,0.00002500655,0.00002224053,0.9970366,0.0002133937,0.00004889307,0.001950014],"study_design_scores_gemma":[0.00001307725,0.0001924138,0.003624339,0.000008182916,0.00001469566,0.0008384062,0.00008071336,0.0000972725,0.9922766,0.0002132172,0.002636365,0.000004621787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856756,0.006721642,0.002995677,0.0003010098,0.0001113937,0.00002257192,0.0002694575,0.00004900002,0.003853575],"genre_scores_gemma":[0.9944844,0.001629313,0.001079947,0.00007039713,0.00002876696,0.00001443318,0.0001625856,0.00001396548,0.002516146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001016298,"threshold_uncertainty_score":0.003399849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074836309051079,"score_gpt":0.2329898468994773,"score_spread":0.2222414838089665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}