{"id":"W2053975578","doi":"10.1038/nsmb1079","title":"Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity","year":2006,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":191,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Royal Society; Michael Smith Health Research BC","keywords":"Serine; Bacteroides thetaiotaomicron; Biochemistry; Threonine; Enzyme; Active site; Biology; Phosphorylation; Rational design; Hydrolase; Chemistry; Bacteroides; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001032033,0.0002656044,0.0002736799,0.0001109385,0.00009666113,0.00002571699,0.0002098195,0.0008292763,0.00009991087],"category_scores_gemma":[0.000144471,0.0002254975,0.0001087109,0.0001380512,0.0002047136,0.000007613696,0.0002196008,0.000422633,7.713576e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001539554,"about_ca_system_score_gemma":0.00006884446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001193524,"about_ca_topic_score_gemma":0.000102709,"domain_scores_codex":[0.9985281,0.0001779084,0.0002370707,0.0005398282,0.000159637,0.0003575171],"domain_scores_gemma":[0.9992278,0.00001285661,0.0001471329,0.0003616734,0.0001579755,0.00009252976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002380628,0.00001069007,0.0007076183,0.0000242285,0.00003716442,0.0000157636,0.000007105347,0.000006366356,0.9867691,0.009388505,0.00005063289,0.002744706],"study_design_scores_gemma":[0.0009098348,0.0003111395,0.008813279,0.000006713827,0.000016952,0.0001151385,0.000006598343,0.000096039,0.9829456,0.005447344,0.001090846,0.0002405399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965881,0.0007618412,0.001527143,0.0001824564,0.0002365728,0.0003240946,0.0002236024,0.00001499931,0.0001411879],"genre_scores_gemma":[0.9972938,0.00001296763,0.001653904,0.0001116225,0.0002353911,0.000007991186,0.0005915799,0.00002536529,0.0000674093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00810566,"threshold_uncertainty_score":0.919552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003413737434284521,"score_gpt":0.2804737883886739,"score_spread":0.2770600509543894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}