{"id":"W2053995146","doi":"10.1021/bi051152f","title":"Autocatalytic Cleavage of Myelin Basic Protein: An Alternative to Molecular Mimicry","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Mimicry; Autocatalysis; Chemistry; Cleavage (geology); Myelin; Molecular mimicry; Biochemistry; Biophysics; Computational biology; Cell biology; Biology; Neuroscience; Genetics; Zoology; Central nervous system; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385733,0.0002042914,0.0001626078,0.00003473952,0.0000426016,0.00002040736,0.0004059356,0.0001523921,0.00004813308],"category_scores_gemma":[0.0001113111,0.0002188366,0.0001248054,0.00009993899,0.00006212971,0.000006388349,0.0001771209,0.00008219389,0.00002499681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003028548,"about_ca_system_score_gemma":0.0001200376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001626396,"about_ca_topic_score_gemma":0.000002059328,"domain_scores_codex":[0.9987609,0.00003173823,0.0002634264,0.0004897791,0.000183146,0.0002709836],"domain_scores_gemma":[0.9989026,0.000003801036,0.0001078474,0.0006470985,0.00008759847,0.0002510477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001134943,0.0001089906,0.00005217924,0.00005897112,0.00003962404,0.000006190547,0.00002729432,0.00009474486,0.984045,0.00003354076,0.0006610734,0.01475891],"study_design_scores_gemma":[0.000359424,0.0001705356,0.00007841461,0.00005381793,0.00001697335,0.000009845919,0.00004516618,0.000116612,0.9937585,0.00004684559,0.005077578,0.0002662847],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950746,0.001829934,0.001343878,0.0002647757,0.00003046895,0.0003417828,0.00007033462,0.00002173297,0.001022492],"genre_scores_gemma":[0.9946198,0.00003929773,0.003959992,0.0004612008,0.0003517474,0.00006187409,0.0001405706,0.00003337522,0.0003320865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01449262,"threshold_uncertainty_score":0.8923899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008054239760816824,"score_gpt":0.2607319121173851,"score_spread":0.2526776723565683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}