{"id":"W2054049637","doi":"10.1074/jbc.m113.504639","title":"Inside-out Signaling Promotes Dynamic Changes in the Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 (CEACAM1) Oligomeric State to Control Its Cell Adhesion Properties","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Cell adhesion; Cell adhesion molecule; Transmembrane protein; Chemistry; Immunoreceptor tyrosine-based activation motif; Tyrosine kinase; Signal transduction; Cell; Biology; SH2 domain; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007633492,0.0002248981,0.0001634854,0.0000618622,0.00009794667,0.0002593518,0.0001163051,0.0002118834,0.001005286],"category_scores_gemma":[0.00007695426,0.00008965189,0.0001421537,0.00005186282,0.0001351218,0.0001820707,0.00014348,0.0004184092,0.0001947513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001580644,"about_ca_system_score_gemma":0.00007845674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001862142,"about_ca_topic_score_gemma":0.0002605429,"domain_scores_codex":[0.9999251,0.00001339026,0.000003209864,0.00001426954,0.00002099231,0.00002303587],"domain_scores_gemma":[0.9999352,0.0000141295,0.00001707421,0.000007010355,0.000007067521,0.00001967686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002099678,0.000009265797,0.00004376479,0.000007165142,8.931568e-7,0.00002020452,0.000006922892,0.000009768431,0.9996543,0.0000405536,0.000008079561,0.0001781806],"study_design_scores_gemma":[0.00000652829,0.0001003647,0.00443732,0.000002777456,0.000005149892,0.0001403995,0.00003225025,0.001227029,0.9931229,0.00004890151,0.0008737242,0.000002826217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982717,0.000369694,0.0007578334,0.00004261278,0.00001043692,0.00000564022,0.00003839775,0.00002201988,0.0004815734],"genre_scores_gemma":[0.998648,0.0002094479,0.0004148882,0.00002868047,0.000005652046,0.000005748147,0.00006763572,0.000008785447,0.0006113403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005286,"threshold_uncertainty_score":0.003363013,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03468095981150471,"score_gpt":0.2711280822520092,"score_spread":0.2364471224405045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}