{"id":"W2054049637","doi":"10.1074/jbc.m113.504639","title":"Inside-out Signaling Promotes Dynamic Changes in the Carcinoembryonic Antigen-related Cellular Adhesion Molecule 1 (CEACAM1) Oligomeric State to Control Its Cell Adhesion Properties","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Cell adhesion; Cell adhesion molecule; Transmembrane protein; Chemistry; Immunoreceptor tyrosine-based activation motif; Tyrosine kinase; Signal transduction; Cell; Biology; SH2 domain; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003812032,0.0002391157,0.0004581602,0.00004232905,0.00008563184,0.00003742796,0.000312458,0.0002129871,0.000218677],"category_scores_gemma":[0.000207787,0.0001310469,0.0001533806,0.0002652556,0.00009775977,0.00005792503,0.00004473662,0.0007259084,0.00004309661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009475807,"about_ca_system_score_gemma":0.00006777287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003674461,"about_ca_topic_score_gemma":1.858447e-7,"domain_scores_codex":[0.9983569,0.00009272346,0.0006170599,0.000266078,0.0002979107,0.0003692766],"domain_scores_gemma":[0.998904,0.0001266857,0.0002832759,0.0002085391,0.0002092523,0.0002682719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001406436,0.0002846999,0.000952644,0.0001729475,0.00002689249,0.00007793812,0.0001943589,0.00004198395,0.9977149,3.954195e-7,0.00005221936,0.0003403369],"study_design_scores_gemma":[0.001066659,0.0003525264,0.003254114,0.0002150999,0.00004904847,0.0001315886,0.0002768474,0.0007091961,0.9935414,0.00005806117,0.000176438,0.0001690087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929519,0.003030778,0.00004060503,0.003020103,0.00002662858,0.000585419,0.000005572531,0.00002322091,0.0003157799],"genre_scores_gemma":[0.9985326,0.0003809009,0.00009982508,0.0005762384,0.0001059059,0.00005238921,0.000009741598,0.00001561823,0.0002268034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005580684,"threshold_uncertainty_score":0.5343935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03468095981150471,"score_gpt":0.2711280822520092,"score_spread":0.2364471224405045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}