{"id":"W2054082210","doi":"10.4161/cc.10.1.14445","title":"An inhibitor of cyclin-dependent kinases suppresses TLR signaling and increases the susceptibility of cancer patients to herpes viridae","year":2011,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Institut National Du Cancer; European Commission","keywords":"Biology; Cyclin-dependent kinase; Cancer research; Kinase; TLR9; Immunosurveillance; Interferon; GSK-3; CDK inhibitor; TLR3; Cyclin A; Cancer; Immunology; Pharmacology; Cell cycle; Innate immune system; Toll-like receptor; Immune system; Cell biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009281876,0.0001169383,0.0002503268,0.0001523289,0.0001130321,0.000146791,0.00008493479,0.0001168623,0.001224365],"category_scores_gemma":[0.0001824522,0.0000691192,0.0001134892,0.0001582748,0.00007982891,0.00007260957,0.0000816185,0.0002587632,0.0001582969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001231778,"about_ca_system_score_gemma":0.0001365888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002769589,"about_ca_topic_score_gemma":0.0003870366,"domain_scores_codex":[0.9999479,0.00001274483,0.000003849651,0.00000823531,0.00001022567,0.00001706059],"domain_scores_gemma":[0.9999362,0.00001658453,0.00001576297,0.000006217077,0.000006120883,0.00001918202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00785744,0.002315813,0.0641383,0.0001586679,0.000107329,0.0005271222,0.0001357293,0.0006787856,0.8239739,0.0002913784,0.001083444,0.09873205],"study_design_scores_gemma":[0.001788382,0.04087854,0.4890802,0.00003316004,0.0002492008,0.00617269,0.0002243109,0.004429943,0.4357079,0.0003063682,0.02110517,0.00002413784],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982203,0.0009173983,0.0001153112,0.00003042281,0.000006733119,0.00002387283,0.00005005684,0.00001382614,0.0006220295],"genre_scores_gemma":[0.9990707,0.0002897859,0.000151546,0.00002088914,0.000005603109,0.00001569924,0.00008828546,0.000002052113,0.0003553713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001224365,"threshold_uncertainty_score":0.004095912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116570072271002,"score_gpt":0.2386150532018549,"score_spread":0.2269580459747547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}