{"id":"W2054088727","doi":"10.4161/15548627.2014.984270","title":"Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine","year":2014,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"Merck KGaA","keywords":"Autophagy; ATG5; BECN1; Biology; Cell biology; Autophagosome; Mitophagy; ATG12; Programmed cell death; Pharmacology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007894877,0.0003530234,0.0002708613,0.0002473335,0.000149158,0.0002127483,0.0001244134,0.0002220729,0.0005829114],"category_scores_gemma":[0.00006178962,0.0001028413,0.0003084207,0.0001323248,0.0001309515,0.0001503846,0.0001279291,0.0003437264,0.0001677432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003874307,"about_ca_system_score_gemma":0.0002779483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530795,"about_ca_topic_score_gemma":0.002690008,"domain_scores_codex":[0.9999381,0.000007411795,0.000004912896,0.000009720532,0.00001643524,0.00002341441],"domain_scores_gemma":[0.9999746,0.000002525587,0.000007348943,0.000002246364,0.000005168492,0.000008047039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003989401,0.00002321193,0.000259046,0.00004585163,0.000007783444,0.0001284765,0.00001033698,0.00004445842,0.9970823,0.00006842892,0.00003787794,0.001893398],"study_design_scores_gemma":[0.0000416445,0.001538987,0.020545,0.0000218338,0.00007181224,0.0009087269,0.00007681835,0.001470915,0.9724449,0.0001956443,0.002669858,0.00001399086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946036,0.002862949,0.0008299443,0.0001214303,0.00003632365,0.00002199947,0.000315125,0.0000643707,0.001144276],"genre_scores_gemma":[0.9954808,0.002088114,0.0007506325,0.00006522801,0.000009356389,0.00002147071,0.0002756135,0.000009500785,0.001299196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001530795,"threshold_uncertainty_score":0.003043711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384470069805358,"score_gpt":0.2708248959565757,"score_spread":0.2569801952585221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}