{"id":"W2054099595","doi":"10.1002/cmdc.201300355","title":"Fluorophore‐Labeled Cyclooxygenase‐2 Inhibitors for the Imaging of Cyclooxygenase‐2 Overexpression in Cancer: Synthesis and Biological Studies","year":2013,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Cancer Foundation","keywords":"Cyclooxygenase; Chemistry; Celecoxib; Fluorophore; Conjugate; Naproxen; In vitro; Enzyme; Cancer; Etodolac; Fluorescence; Pharmacology; Biochemistry; Stereochemistry; Medicine; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004609263,0.0003893033,0.0003026481,0.0002676823,0.0001841988,0.000189173,0.0003346542,0.0003999996,0.0009036293],"category_scores_gemma":[0.0001591032,0.0002117145,0.0001819602,0.0002053424,0.0001816275,0.0003033058,0.0001316706,0.0003972947,0.0002659423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004789083,"about_ca_system_score_gemma":0.0002445796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009153347,"about_ca_topic_score_gemma":0.001468178,"domain_scores_codex":[0.9998977,0.00003005359,0.000004242735,0.00001928393,0.00002417164,0.00002447645],"domain_scores_gemma":[0.9999255,0.00002359183,0.00001440818,0.000006969903,0.00001438909,0.0000151124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008342905,0.00003632139,0.00004512306,0.00006848551,0.000003773653,0.00002808357,0.00001835168,0.0001345651,0.9971924,0.0001768735,0.00004950933,0.00216308],"study_design_scores_gemma":[0.00002004519,0.0002987868,0.0004404198,0.000004365519,0.000008563246,0.0001385485,0.000005624307,0.000779193,0.9961628,0.00002024927,0.002117318,0.000004131464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9272538,0.01615981,0.05059671,0.0003256772,0.00005458784,0.0003513495,0.0004104379,0.0001982424,0.004649275],"genre_scores_gemma":[0.9300635,0.008969095,0.05588033,0.0001297608,0.00004010232,0.0003140307,0.000487967,0.00003102815,0.004084243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009153347,"threshold_uncertainty_score":0.003474712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03143454628152326,"score_gpt":0.3032597648714837,"score_spread":0.2718252185899604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}