{"id":"W2054103222","doi":"10.1016/j.stem.2012.12.011","title":"A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition","year":2013,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Canada's Michael Smith Genome Sciences Centre; Ontario Institute for Cancer Research; BC Cancer Agency","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Ontario Ministry of Research and Innovation; University of California, San Diego; Canadian Institutes of Health Research; Ontario Genomics Institute; China Scholarship Council; Genome Canada; National Institutes of Health; Ontario Genomics; National Cancer Institute; Government of Canada; California Institute for Regenerative Medicine","keywords":"Biology; Stem cell; Tyrosine-kinase inhibitor; Leukemia; Bone marrow; Cancer research; Tyrosine kinase; Immunology; Cell biology; Signal transduction; Cancer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000179654,0.0004144062,0.0004159794,0.00034766,0.0002210283,0.0004516045,0.0003040029,0.0002831206,0.002556616],"category_scores_gemma":[0.0001171047,0.000161298,0.0002171341,0.0003236996,0.0002581875,0.0002774524,0.0001859619,0.0009422007,0.0004073671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002880316,"about_ca_system_score_gemma":0.0003079365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006827065,"about_ca_topic_score_gemma":0.001301047,"domain_scores_codex":[0.9998385,0.00002130501,0.00001665561,0.00003208642,0.00004470061,0.00004667611],"domain_scores_gemma":[0.9999158,0.00002082572,0.00001598596,0.00001280765,0.000007463942,0.00002705395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006032383,0.0002025887,0.0002256106,0.00003068361,0.00001662575,0.00006646262,0.00002437547,0.0002187707,0.9935482,0.000446775,0.0003099206,0.00430688],"study_design_scores_gemma":[0.0001332648,0.000619731,0.001348108,0.000003219708,0.00002314995,0.0002757833,0.00003136418,0.001217575,0.9927568,0.00008648173,0.003499533,0.00000490324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909742,0.001340184,0.002691379,0.0002148339,0.00009974993,0.00007182238,0.000834678,0.0002890197,0.003484086],"genre_scores_gemma":[0.9956605,0.0005280119,0.001191078,0.00004928265,0.00001107906,0.0000373053,0.0006990253,0.00002528267,0.001798492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002556616,"threshold_uncertainty_score":0.00855273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01464464361081714,"score_gpt":0.234219884548629,"score_spread":0.2195752409378119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}