{"id":"W2054103986","doi":"10.1016/j.bmcl.2012.10.126","title":"From a cytotoxic agent to the discovery of a novel antimalarial agent","year":2012,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Malaria Research and Control","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Plasmodium falciparum; Antimalarial Agent; Glutathione; IC50; Cytotoxicity; Stereochemistry; Cytotoxic T cell; Drug; Pharmacology; In vitro; Combinatorial chemistry; Drug discovery; Biochemistry; Malaria; Enzyme; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004328249,0.0004468733,0.0005574519,0.0007764639,0.0004967348,0.001874779,0.0006432857,0.000976789,0.003305868],"category_scores_gemma":[0.0005502134,0.0003723453,0.0003218223,0.0003677792,0.001511395,0.002760775,0.001269426,0.002616748,0.001697024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000836233,"about_ca_system_score_gemma":0.0006976008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003901474,"about_ca_topic_score_gemma":0.0007027391,"domain_scores_codex":[0.9998288,0.00002944746,0.00001545852,0.00003005966,0.00006430531,0.00003177708],"domain_scores_gemma":[0.9997711,0.00005909093,0.00002066263,0.00002963106,0.00006640059,0.00005326114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009238345,0.0004553244,0.0008337689,0.003783153,0.00008885769,0.002200696,0.0007945211,0.002278686,0.4075573,0.1716017,0.02214775,0.3873345],"study_design_scores_gemma":[0.0001681189,0.001593383,0.0008138255,0.0005944076,0.0000935347,0.002407695,0.0003844546,0.002238892,0.201663,0.08510862,0.704849,0.00008499384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1532779,0.5762547,0.06451182,0.07059333,0.007655133,0.000363247,0.0009217163,0.0008660366,0.125556],"genre_scores_gemma":[0.5244471,0.3765471,0.02464652,0.01565077,0.002586427,0.0001756499,0.0005350921,0.0001479472,0.0552634],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003305868,"threshold_uncertainty_score":0.01105928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02260729087551789,"score_gpt":0.2704443685667315,"score_spread":0.2478370776912137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}