{"id":"W2054115083","doi":"10.1016/j.mehy.2012.12.024","title":"Increasing the clozapine: Norclozapine ratio with co-administration of fluvoxamine to enhance efficacy and minimize side effects of clozapine therapy","year":2013,"lang":"en","type":"article","venue":"Medical Hypotheses","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut national de psychiatrie légale Philippe-Pinel","funders":"","keywords":"Clozapine; Pharmacology; Fluvoxamine; Antipsychotic; Tolerability; Atypical antipsychotic; Medicine; Dose; Side effect (computer science); Schizophrenia (object-oriented programming); Adverse effect; Internal medicine; Psychiatry; Fluoxetine; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004600443,0.0006073635,0.001414239,0.0007293713,0.0004299792,0.0008878405,0.0007632377,0.0007795974,0.00249642],"category_scores_gemma":[0.002008632,0.000274045,0.0003917842,0.0002924505,0.0004050047,0.0009198004,0.0005204684,0.001318073,0.0006153513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004864408,"about_ca_system_score_gemma":0.0008916822,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000696591,"about_ca_topic_score_gemma":0.00241528,"domain_scores_codex":[0.9993823,0.0001489532,0.0001063121,0.0001105681,0.0001285414,0.0001234246],"domain_scores_gemma":[0.9995205,0.0001142368,0.000120136,0.00004632067,0.00004325916,0.0001555911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.065309,0.01424621,0.003818732,0.0004168872,0.0005029197,0.0004063046,0.000175768,0.001045171,0.7649587,0.0009110052,0.001802176,0.1464072],"study_design_scores_gemma":[0.02063119,0.08947416,0.0517782,0.0001256199,0.001558367,0.003031146,0.0003279658,0.0112215,0.8029408,0.001308363,0.01738203,0.0002207477],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916373,0.001456055,0.002863789,0.0008875882,0.0002482195,0.0003782329,0.0001042759,0.0002828812,0.002141614],"genre_scores_gemma":[0.9916016,0.000649499,0.006278795,0.0002081796,0.0001890148,0.0001489463,0.00007671159,0.00005465443,0.0007925533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00249642,"threshold_uncertainty_score":0.008351386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550450602658055,"score_gpt":0.3107113537128665,"score_spread":0.2952068476862859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}