{"id":"W2054172055","doi":"10.1002/cncr.22961","title":"Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors","year":2007,"lang":"en","type":"article","venue":"Cancer","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"National Cancer Institute","keywords":"Temozolomide; Medicine; Medulloblastoma; Ependymoma; Astrocytoma; Context (archaeology); Glioma; Phases of clinical research; Primitive neuroectodermal tumor; Internal medicine; Oncology; Chemotherapy; Oligodendroglioma; Radiation therapy; Surgery; Pathology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001015068,0.0007725389,0.001350866,0.0002471325,0.0002283144,0.0003795825,0.0005034676,0.0005278725,0.001475736],"category_scores_gemma":[0.0005860148,0.0002414859,0.0004977009,0.0002629664,0.0003945327,0.0002753353,0.0002549512,0.001822713,0.000325528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006601284,"about_ca_system_score_gemma":0.001639694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001788473,"about_ca_topic_score_gemma":0.003242622,"domain_scores_codex":[0.9997489,0.000124202,0.0000152711,0.0000326205,0.00003159755,0.00004743874],"domain_scores_gemma":[0.9994282,0.00008580202,0.0001124153,0.00003137082,0.00006279918,0.0002793726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4169978,0.1117884,0.10905,0.001910971,0.003469079,0.002086564,0.001241132,0.005130182,0.1061703,0.000525147,0.009457989,0.2321726],"study_design_scores_gemma":[0.2454625,0.6454422,0.07754306,0.00009792497,0.001088706,0.002529057,0.0002203603,0.002056064,0.01287284,0.0001566132,0.01250483,0.00002583765],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959948,0.001470839,0.0003193907,0.0001441562,0.00002951233,0.001044602,0.0004336784,0.00002827971,0.0005346464],"genre_scores_gemma":[0.9898858,0.002773903,0.00190855,0.000392217,0.00007591135,0.00193295,0.001958066,0.00002284264,0.001049796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788473,"threshold_uncertainty_score":0.005368233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043103189606357,"score_gpt":0.28917638506221,"score_spread":0.2787453531661464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}