{"id":"W2054216757","doi":"10.1016/j.gep.2013.10.003","title":"Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation","year":2013,"lang":"en","type":"article","venue":"Gene Expression Patterns","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; Hotchkiss Brain Institute; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"PAX6; Biology; Homeobox; HES1; Progenitor cell; Genetics; Transcription factor; Gene; Embryonic stem cell; Cellular differentiation; Cell biology; Gene expression; Basic helix-loop-helix; Molecular biology; Notch signaling pathway; Stem cell; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007008142,0.0002330297,0.0001687447,0.00009289337,0.00009791218,0.00006244277,0.0001723994,0.000193258,0.0001704717],"category_scores_gemma":[0.00001785266,0.0002057156,0.00005335452,0.00007419415,0.00001906152,0.00001576702,0.0003007832,0.00009109162,0.00002622661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002251314,"about_ca_system_score_gemma":0.00002222261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003389671,"about_ca_topic_score_gemma":0.000006350593,"domain_scores_codex":[0.9984639,0.00007202139,0.0003246145,0.0005807382,0.0002264376,0.0003322809],"domain_scores_gemma":[0.9993472,0.00000562032,0.0001013647,0.0003119181,0.00006395999,0.0001699511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001183882,0.000056316,0.07110538,0.00003839945,0.000006852224,0.000003752282,0.0001991615,0.00001093179,0.9272178,1.079551e-7,0.0006874992,0.000555444],"study_design_scores_gemma":[0.000619464,0.00006237133,0.192617,0.00009771132,0.00000414382,0.000002763355,0.00005080325,0.00007306452,0.8061042,0.00001232315,0.0001236325,0.0002325077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965494,0.0001260626,0.002411339,0.0001381475,0.0001314496,0.0005753085,0.00001523762,0.00001836926,0.00003464402],"genre_scores_gemma":[0.9952804,0.000101884,0.003286938,0.0001423257,0.00009646596,0.0001154031,0.0001905105,0.00003313522,0.000752936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1215116,"threshold_uncertainty_score":0.8388836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003983612051951985,"score_gpt":0.2025143360000152,"score_spread":0.1985307239480632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}