{"id":"W2054216998","doi":"10.1016/j.bmcl.2007.05.067","title":"Optimization of novel combi-molecules: Identification of balanced and mixed bcr-abl/DNA targeting properties","year":2007,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Leukemia and Lymphoma Society","keywords":"Chemistry; Chronic myelogenous leukemia; ABL; DNA; Tyrosine kinase; Imatinib mesylate; DNA damage; Molecule; Imatinib; Cancer research; In vitro; Molecular biology; Biochemistry; Leukemia; Signal transduction; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000298582,0.0003371904,0.0003058527,0.0002428503,0.0001273816,0.0004759178,0.0002394671,0.000352443,0.001805855],"category_scores_gemma":[0.0004487353,0.00018918,0.0001270936,0.0002224721,0.000130425,0.0003797589,0.000193813,0.0003248422,0.0004635944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003296932,"about_ca_system_score_gemma":0.0001934462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001680143,"about_ca_topic_score_gemma":0.0005058445,"domain_scores_codex":[0.9998609,0.00002328299,0.00001333949,0.00002960011,0.00005400731,0.00001882761],"domain_scores_gemma":[0.9998622,0.00003415509,0.00004232939,0.00001062619,0.00002984454,0.0000208859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004170145,0.0001772785,0.0003042397,0.00007737392,0.00001481986,0.0000300121,0.00001820838,0.001436477,0.9814854,0.0004642958,0.0002076384,0.01536724],"study_design_scores_gemma":[0.0001321268,0.0005240622,0.00050338,0.000003941416,0.00002267999,0.0000709594,0.000008775624,0.006856788,0.988349,0.00005178155,0.003468347,0.000008224422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796869,0.001559089,0.01438719,0.0001693422,0.00004024247,0.0002097672,0.0004182068,0.00016941,0.003359891],"genre_scores_gemma":[0.9756178,0.000602151,0.02062286,0.00008969555,0.00001440218,0.0001632474,0.0003845166,0.00004627936,0.002459013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805855,"threshold_uncertainty_score":0.006041169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340985493249317,"score_gpt":0.2314976782259793,"score_spread":0.2180878232934861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}