{"id":"W2054222279","doi":"10.1038/ni1169","title":"Selective regulation of tumor necrosis factor–induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase","year":2005,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"Protein tyrosine phosphatase; MAPK/ERK pathway; Cell biology; Kinase; Proinflammatory cytokine; Proto-oncogene tyrosine-protein kinase Src; Tyrosine kinase; Signal transduction; Mitogen-activated protein kinase; Biology; Receptor tyrosine kinase; Cancer research; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001991471,0.000225416,0.000287787,0.0000609559,0.00008249412,0.00001768398,0.0002413492,0.0003854946,0.00001223559],"category_scores_gemma":[0.0002809984,0.0001773898,0.00006546033,0.0001971308,0.0002576938,0.00001463789,0.0001332868,0.0004170569,0.00000208303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003380657,"about_ca_system_score_gemma":0.00007247349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030912,"about_ca_topic_score_gemma":0.0000361509,"domain_scores_codex":[0.9987077,0.0001679753,0.0003217573,0.0003955175,0.0001217665,0.0002853272],"domain_scores_gemma":[0.9991854,0.0000608439,0.0002431789,0.0003538919,0.00012691,0.00002976244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001023848,0.00009120459,0.0001995477,0.0000190193,0.00004066672,9.425826e-7,0.00004595194,0.00001432795,0.9953433,0.0008151907,0.0006037786,0.001802201],"study_design_scores_gemma":[0.002673208,0.0002879976,0.005522136,0.00003377429,0.00001727149,0.000006360001,0.00003152817,0.00002993178,0.9890027,0.0001946967,0.002017803,0.0001825815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8746773,0.1239566,0.00005322858,0.0003370412,0.00005963544,0.0006772258,0.0001761521,0.00001224617,0.00005057577],"genre_scores_gemma":[0.998349,0.0002130805,0.0005965809,0.000323683,0.00006357059,0.0000952238,0.0002629426,0.00002502406,0.00007091188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1237435,"threshold_uncertainty_score":0.7233747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004204986112124344,"score_gpt":0.2175518749351882,"score_spread":0.2133468888230639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}