{"id":"W2054257521","doi":"10.1039/c3cp54151g","title":"pH changes the aggregation propensity of amyloid-β without altering the monomer conformation","year":2013,"lang":"en","type":"article","venue":"Physical Chemistry Chemical Physics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Monomer; Chemistry; Biophysics; Protein aggregation; Amyloid (mycology); Peptide; Conformational change; Amyloid fibril; Solubility; Amyloid β; Stereochemistry; Biochemistry; Polymer; Organic chemistry; Biology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342909,0.0002352107,0.000124505,0.00007806136,0.0001220999,0.0002602817,0.0001118565,0.0002864597,0.001346644],"category_scores_gemma":[0.0002650031,0.000157517,0.0001189276,0.00008671032,0.000231941,0.0002890611,0.0001376338,0.0003531673,0.0002623436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008837174,"about_ca_system_score_gemma":0.00009110058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002277513,"about_ca_topic_score_gemma":0.0002948781,"domain_scores_codex":[0.9999126,0.00001623153,0.000007905655,0.00002445829,0.00002113038,0.00001765927],"domain_scores_gemma":[0.999845,0.00006798993,0.00004287196,0.00001121418,0.00001753339,0.00001531038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009074054,0.00001717673,0.0004967891,0.00003792974,0.000007462252,0.0000377805,0.00002109216,0.00007619384,0.9979044,0.00003789738,0.00003023786,0.001242163],"study_design_scores_gemma":[0.00001062516,0.0002221544,0.006495098,0.000005483268,0.00001123748,0.0002016272,0.00004371507,0.0005208337,0.991663,0.0001392298,0.0006795485,0.000007452125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959756,0.0006585297,0.001620838,0.00009706553,0.00003225404,0.0000100385,0.0001097196,0.00003999809,0.001455955],"genre_scores_gemma":[0.9975425,0.0005585839,0.001255133,0.00008884043,0.000008320891,0.000008909509,0.00008191227,0.0000107711,0.0004449836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346644,"threshold_uncertainty_score":0.004504979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03255035247923206,"score_gpt":0.284889215367011,"score_spread":0.2523388628877789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}