{"id":"W2054262227","doi":"10.1016/j.toxicon.2010.11.013","title":"Antiarrhythmogenic effects of a neurotoxin from the spider Phoneutria nigriventer","year":2010,"lang":"en","type":"article","venue":"Toxicon","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Atropine; Acetylcholine; Muscarinic acetylcholine receptor; Pharmacology; Anesthesia; Bradycardia; Chemistry; Pyridostigmine; Neuromuscular junction; Spider toxin; Internal medicine; Spider; Heart rate; Medicine; Receptor; Biology; Neuroscience; Glutamate receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005506238,0.000192445,0.0001511349,0.0001865533,0.0001384887,0.0001485069,0.000111697,0.0003156785,0.0005544709],"category_scores_gemma":[0.0001236378,0.00005840187,0.00009433803,0.00008736343,0.0001321223,0.0001081015,0.0001113538,0.000288035,0.00009203047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009041548,"about_ca_system_score_gemma":0.00009856073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003836089,"about_ca_topic_score_gemma":0.0005034639,"domain_scores_codex":[0.9999639,0.000007617148,0.000002594304,0.000005938433,0.00001067088,0.000009161785],"domain_scores_gemma":[0.9999309,0.00001872907,0.00001595606,0.000006920068,0.000008871251,0.00001867706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001598375,0.00001133857,0.0002072803,0.00001433149,0.000004473694,0.000133518,0.000008644251,0.00001881268,0.9984173,0.00003384545,0.00001204077,0.0009785511],"study_design_scores_gemma":[0.00007137006,0.001848273,0.03149731,0.0000144388,0.00005183445,0.001701609,0.00006428572,0.0006250837,0.9619255,0.0001716436,0.002020194,0.000008478689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980441,0.0006999174,0.0002712476,0.00003959373,0.000006604369,0.00000586527,0.00005120673,0.00001113883,0.0008701549],"genre_scores_gemma":[0.998365,0.0004493276,0.0003186314,0.00003372399,0.000007362333,0.000004158992,0.0001353836,0.000004914775,0.000681522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005544709,"threshold_uncertainty_score":0.001854897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005280812029131382,"score_gpt":0.2206503335737483,"score_spread":0.2153695215446169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}