{"id":"W2054301876","doi":"10.1021/cb400133j","title":"An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":466,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; National Institute of Mental Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"EZH2; Histone H3; Methyltransferase; Histone methyltransferase; Epigenetics; Lysine; Biology; Histone; PRC2; Methylation; Acetylation; Histone H4; Biochemistry; Cell biology; Chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272873,0.0001551404,0.0002021893,0.0000201227,0.00003478402,0.00001313636,0.000267515,0.0003033662,0.00004822705],"category_scores_gemma":[0.0001487708,0.0001058155,0.00006474365,0.00009930051,0.0003661834,0.00000552225,0.0001223083,0.0001027025,0.00000577289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000571893,"about_ca_system_score_gemma":0.00003606664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007156017,"about_ca_topic_score_gemma":0.000004224031,"domain_scores_codex":[0.9989967,0.00007969206,0.0002622489,0.0003630295,0.00006727782,0.0002310447],"domain_scores_gemma":[0.9992844,0.00003481083,0.00007296826,0.0003947171,0.0001232318,0.00008982873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002205914,0.00007124901,0.007959173,0.00001310448,0.00002672508,7.719473e-8,0.00001528401,9.260345e-7,0.9874216,0.0001800849,0.000110767,0.004178995],"study_design_scores_gemma":[0.0003203104,0.0001866259,0.001143666,0.000005231351,0.00002023726,0.000002635756,0.00001101599,0.00002235372,0.9934663,0.001775559,0.002906451,0.0001396598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997436,0.001153907,0.0003683241,0.0004831378,0.000050292,0.0002245253,0.00001947013,0.000009550311,0.0002547331],"genre_scores_gemma":[0.9970121,0.0002544554,0.002159258,0.0002090649,0.0001120409,0.00002977699,0.0001436189,0.00001540962,0.0000642708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006815506,"threshold_uncertainty_score":0.4315029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008831481858498134,"score_gpt":0.2465433659088719,"score_spread":0.2377118840503738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}