{"id":"W2054301876","doi":"10.1021/cb400133j","title":"An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":466,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Cancer Institute; National Institute of Mental Health; National Institute of General Medical Sciences; Wellcome Trust","keywords":"EZH2; Histone H3; Methyltransferase; Histone methyltransferase; Epigenetics; Lysine; Biology; Histone; PRC2; Methylation; Acetylation; Histone H4; Biochemistry; Cell biology; Chemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147982,0.0003918582,0.0001698358,0.0001640482,0.0001295779,0.0001559603,0.0003304982,0.0003921949,0.001930807],"category_scores_gemma":[0.0001075021,0.0001359947,0.0001828864,0.0001344617,0.0001437918,0.0001901622,0.0001560268,0.0004568138,0.0004304804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003526107,"about_ca_system_score_gemma":0.0001938836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005250821,"about_ca_topic_score_gemma":0.0007609145,"domain_scores_codex":[0.9999187,0.00001407634,0.000004238249,0.00002211748,0.00001922403,0.00002157661],"domain_scores_gemma":[0.9999554,0.00000792312,0.00001338738,0.000005891013,0.00000608307,0.0000113449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002042591,0.00008858731,0.00009506833,0.0000909501,0.000008482913,0.000109683,0.0000142426,0.000350673,0.9925891,0.000458414,0.000219087,0.00577144],"study_design_scores_gemma":[0.00007263301,0.001622475,0.0004707003,0.000006246508,0.00002112552,0.0002862043,0.00001157654,0.00054978,0.9862173,0.00006821709,0.01066672,0.000006993403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532116,0.009977616,0.01674652,0.0004601633,0.0001195223,0.0002626522,0.001554377,0.0002146469,0.01745282],"genre_scores_gemma":[0.9838524,0.003242009,0.005368184,0.0001641191,0.0000203084,0.0000833271,0.0007375486,0.00001589707,0.006516157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001930807,"threshold_uncertainty_score":0.006459177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008831481858498134,"score_gpt":0.2465433659088719,"score_spread":0.2377118840503738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}