{"id":"W2054312886","doi":"10.1073/pnas.0911828107","title":"Differential control of TAp73 and ΔNp73 protein stability by the ring finger ubiquitin ligase PIR2","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"European Commission","keywords":"Gene isoform; Ubiquitin ligase; Ring finger; Biology; Transcription factor; Apoptosis; Ubiquitin; Cell biology; Promoter; Transcription (linguistics); DNA damage; Molecular biology; Gene expression; Gene; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161128,0.00009228074,0.0002037166,0.00006806718,0.0001333032,0.00001519434,0.0003410552,0.00009852003,0.00004074332],"category_scores_gemma":[0.001264787,0.00005204267,0.00007346041,0.0002976322,0.001425874,0.0001331601,0.0001020884,0.0003822217,2.503922e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001944149,"about_ca_system_score_gemma":0.00006065914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001400242,"about_ca_topic_score_gemma":3.444184e-7,"domain_scores_codex":[0.9983305,0.000008122175,0.0003272388,0.0002161631,0.0009775291,0.0001404645],"domain_scores_gemma":[0.9991515,0.0001060298,0.00039413,0.00001668136,0.0002849104,0.00004680351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000571399,0.00005755703,0.003032187,0.0001071551,0.00001728507,4.832086e-9,0.0001844764,0.000001293466,0.9920182,0.004009894,0.0001074597,0.0004073324],"study_design_scores_gemma":[0.0006394444,0.00008690781,0.01829585,0.0001436204,0.00003742277,0.000009422482,0.00008985111,0.0007073659,0.9766858,0.003149471,0.0001034036,0.00005141108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927615,0.0001508212,0.000006513123,0.005429661,0.00002213979,0.0005624925,0.00003288922,0.00000817698,0.001025816],"genre_scores_gemma":[0.9994656,0.000006708997,0.000236477,0.000158037,0.00006536814,0.00002324422,1.488474e-7,0.000004618531,0.00003980525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01533238,"threshold_uncertainty_score":0.525369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02119422407620048,"score_gpt":0.2745066896566384,"score_spread":0.253312465580438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}