{"id":"W2054312934","doi":"10.1152/ajpendo.00540.2002","title":"Differential activation of NF-κB and AP-1 in increased fibronectin synthesis in target organs of diabetic complications","year":2003,"lang":"en","type":"article","venue":"American Journal of Physiology-Endocrinology and Metabolism","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Downregulation and upregulation; Fibronectin; Endocrinology; Internal medicine; Extracellular matrix; Cell biology; Bosentan; Retina; Biology; Endothelin 1; Diabetes mellitus; Chemistry; Receptor; Medicine; Endothelin receptor; Biochemistry; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283179,0.0001012878,0.0004105556,0.0002220233,0.00002573692,0.000001642868,0.0001050428,0.00004781164,0.0000203163],"category_scores_gemma":[0.0006798059,0.00009083832,0.00003482978,0.0002062487,0.0005506753,0.00001247652,0.00004290719,0.0001790069,1.874416e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006670332,"about_ca_system_score_gemma":0.00007815619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006610476,"about_ca_topic_score_gemma":0.000006848392,"domain_scores_codex":[0.9987692,0.0004270258,0.0003651807,0.0001883195,0.00006199736,0.0001883219],"domain_scores_gemma":[0.9991506,0.0001577165,0.0003569369,0.0001617175,0.0001268755,0.00004609039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001650607,0.0001250545,0.01070514,0.0000201297,0.00004946589,4.10905e-7,0.00008605871,0.0000609601,0.9839154,0.0007889786,0.000006788293,0.004076566],"study_design_scores_gemma":[0.0005319013,0.0001554412,0.3823501,0.00001292656,0.00001383869,0.00002070733,0.000208128,0.000005066662,0.6153947,0.0008624239,0.0003855563,0.00005923958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985042,0.0007215701,0.000425617,0.000175897,0.00003259199,0.00008717508,0.000009584007,0.000001180853,0.00004219487],"genre_scores_gemma":[0.996726,0.001190484,0.001994468,0.0000331314,0.00002657806,0.000009085356,0.000006111084,0.000008114516,0.000005975679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3716449,"threshold_uncertainty_score":0.3704279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008102849179947127,"score_gpt":0.2627349724941229,"score_spread":0.2546321233141758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}