{"id":"W2054338414","doi":"10.1073/pnas.1934711100","title":"Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins","year":2003,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Lunenfeld-Tanenbaum Research Institute; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Signal transducing adaptor protein; GRB2; Cell biology; FADD; Signal transduction; Biology; Receptor tyrosine kinase; Phosphotyrosine-binding domain; Death domain; SH2 domain; Syk; Tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; Effector; Programmed cell death; Caspase; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007694335,0.00008919647,0.00009530778,0.00005293697,0.000201772,0.0000179796,0.000266617,0.00007820918,0.000005723823],"category_scores_gemma":[0.0004090958,0.00006286355,0.00005226125,0.0003993274,0.0001448385,0.00002971612,0.00005643824,0.00006320685,3.637708e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001279792,"about_ca_system_score_gemma":0.00003885678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007868789,"about_ca_topic_score_gemma":1.483199e-7,"domain_scores_codex":[0.9989134,0.00001039129,0.0002117173,0.0002676708,0.0004579369,0.0001388554],"domain_scores_gemma":[0.9995273,0.00001041136,0.0002184451,0.00001216281,0.0001896252,0.00004200979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001140006,0.00003745991,0.0001076481,0.00001838838,0.000005345325,4.67276e-9,0.00009223798,0.0004375911,0.9887278,0.01018407,0.00003329828,0.0003447653],"study_design_scores_gemma":[0.0001038276,0.0001638821,0.0008683818,0.00004287076,0.000006063594,0.000007101088,0.0001662065,0.0002727079,0.993454,0.004326943,0.0005023234,0.00008571482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977478,0.0001446426,0.00007245997,0.0002762722,0.00002761717,0.0002510244,0.000006918303,0.000005838972,0.001467406],"genre_scores_gemma":[0.9855731,0.00001098179,0.01397082,0.0001605196,0.0001093958,0.00001291772,5.987561e-7,0.000006037822,0.0001556367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01389836,"threshold_uncertainty_score":0.2563501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03669257880848476,"score_gpt":0.2900105370471593,"score_spread":0.2533179582386746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}