{"id":"W2054340359","doi":"10.1002/ijc.21827","title":"<i>In vitro</i> and <i>in vivo</i> evaluation of WK‐X‐34, a novel inhibitor of P‐glycoprotein and BCRP, using radio imaging techniques","year":2006,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"University of Toronto; Deutsche Forschungsgemeinschaft; Government of Canada","keywords":"P-glycoprotein; In vivo; Mitoxantrone; Abcg2; Daunorubicin; Pharmacology; In vitro; Efflux; Transfection; Flow cytometry; Chemistry; Cell culture; Molecular biology; Multiple drug resistance; Biology; Medicine; Internal medicine; ATP-binding cassette transporter; Biochemistry; Transporter; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003106582,0.0006258109,0.0002948719,0.0002538675,0.0001438589,0.0003340871,0.0003853593,0.0003902499,0.0008755374],"category_scores_gemma":[0.0002096753,0.0003687378,0.0002504199,0.0001311992,0.0002793726,0.0003514398,0.0001383233,0.0007233567,0.000400399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004410517,"about_ca_system_score_gemma":0.0002314685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008289354,"about_ca_topic_score_gemma":0.0008263091,"domain_scores_codex":[0.9998375,0.00006828072,0.000007283081,0.00002538537,0.00003176675,0.00002968445],"domain_scores_gemma":[0.9998378,0.00003350851,0.00006616847,0.00001527064,0.00002277428,0.00002448334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002905625,0.0001051851,0.00009825369,0.00006623838,0.000008510819,0.00003141072,0.00001102454,0.0003931989,0.9965129,0.0000958357,0.0001395185,0.002247375],"study_design_scores_gemma":[0.00004407748,0.001754669,0.0007746633,0.000003649448,0.00003021366,0.0002295735,0.000007365777,0.0009915094,0.9943689,0.00001944889,0.001770795,0.000005162508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706877,0.009280553,0.01372996,0.0005553763,0.00005708609,0.0002024712,0.0004853708,0.000322456,0.004678937],"genre_scores_gemma":[0.9780692,0.006146609,0.01088195,0.0001667348,0.00005260961,0.0001737369,0.0009199186,0.00008499604,0.003504247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008755374,"threshold_uncertainty_score":0.003199995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01260067169212413,"score_gpt":0.312793285475815,"score_spread":0.3001926137836909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}