{"id":"W2054394765","doi":"10.1128/aac.00315-15","title":"Subtype-Specific Analysis of the K65R Substitution in HIV-1 That Confers Hypersusceptibility to a Novel Nucleotide-Competing Reverse Transcriptase Inhibitor","year":2015,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada); McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research","keywords":"Reverse transcriptase; Nucleotide; Biology; Virology; Recombinant DNA; Reverse-transcriptase inhibitor; Lentivirus; Nucleotidyltransferase; Virus; Molecular biology; Genetics; Gene; RNA; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002117363,0.00019148,0.0002222571,0.0001453167,0.0001105469,0.0001791485,0.0001631416,0.0002229903,0.0006443307],"category_scores_gemma":[0.000235918,0.000121266,0.0002846875,0.0001845108,0.0001181055,0.0001036542,0.00006305434,0.000310867,0.0002008886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002404796,"about_ca_system_score_gemma":0.0001979108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002694224,"about_ca_topic_score_gemma":0.002126836,"domain_scores_codex":[0.9998505,0.00003666441,0.00002037438,0.00002638611,0.00003401099,0.00003209366],"domain_scores_gemma":[0.9998589,0.00003641827,0.00004024482,0.00002048674,0.00002310986,0.00002081798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001453424,0.00005687805,0.0008030873,0.00001020245,0.000006117293,0.00003563671,0.00001408904,0.0001098872,0.998224,0.00003387454,0.00001484479,0.0005462084],"study_design_scores_gemma":[0.00005462877,0.003319305,0.03463208,0.000007904064,0.00005229808,0.0009505963,0.00009436467,0.00430606,0.9554718,0.00003861872,0.001057038,0.00001532082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992859,0.00009289909,0.0003077603,0.000007299765,0.000002713626,0.000009812477,0.00011881,0.000006252872,0.0001685104],"genre_scores_gemma":[0.9979185,0.0001088207,0.00111906,0.00002135056,0.000002623356,0.00001060998,0.000396218,0.00001080665,0.0004119899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002694224,"threshold_uncertainty_score":0.005357146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04594358360502291,"score_gpt":0.2670860888215788,"score_spread":0.2211425052165559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}