{"id":"W2054395562","doi":"10.1016/j.jbiotec.2010.09.959","title":"High productivity of human recombinant beta-interferon from a low-temperature perfusion culture","year":2010,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Chinese hamster ovary cell; Glycosylation; Recombinant DNA; Perfusion; Chemistry; Cell culture; Fucose; Biochemistry; Biology; Glycoprotein; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472791,0.0001578397,0.0003007775,0.0001019201,0.00008866665,0.00001382338,0.0003122481,0.0007200603,0.0000731988],"category_scores_gemma":[0.00009596248,0.0001149355,0.0001935981,0.00009699284,0.0001649873,0.00000846381,0.0001500381,0.000641212,0.00000197103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009751362,"about_ca_system_score_gemma":0.00005560209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004639623,"about_ca_topic_score_gemma":0.0000845076,"domain_scores_codex":[0.9990418,0.00005191448,0.000375733,0.000246324,0.0001248451,0.0001593717],"domain_scores_gemma":[0.9988736,0.000005224889,0.0004643432,0.0004097026,0.0001804847,0.00006667324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00019373,0.0002920287,0.0007373021,0.00001432128,0.00005861529,0.000008553669,0.00003711027,0.000004318804,0.9905081,0.0001218364,0.006667341,0.001356778],"study_design_scores_gemma":[0.0006334562,0.002264073,0.002053809,0.00005470696,0.00003454307,0.00008503609,0.00005427373,6.630812e-7,0.9898852,0.0007987676,0.004009206,0.0001262339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971429,0.0005444037,0.0000325098,0.0006867711,0.001442109,0.00009108244,0.00002364042,0.00001099827,0.00002556355],"genre_scores_gemma":[0.998542,0.0002320556,0.0004146015,0.00005188768,0.0005522207,0.000002510323,0.00002675483,0.00001544672,0.0001625695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002658135,"threshold_uncertainty_score":0.5553765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004210963888085249,"score_gpt":0.2373270756630036,"score_spread":0.2331161117749183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}