{"id":"W2054402484","doi":"10.1021/ja8014023","title":"A Platinum Supramolecular Square as an Effective G-Quadruplex Binder and Telomerase Inhibitor","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Chemistry; G-quadruplex; Supramolecular chemistry; Telomerase; Platinum; Hydrogen bond; DNA; Ethylenediamine; Duplex (building); Combinatorial chemistry; Molecular model; Stereochemistry; Biophysics; Crystallography; Biochemistry; Molecule; Organic chemistry; Crystal structure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009159701,0.0001677332,0.000200341,0.000100877,0.0001137535,0.0002414986,0.0002486373,0.0002380773,0.001080996],"category_scores_gemma":[0.0001477701,0.0001238895,0.00008225867,0.00008610281,0.000157713,0.0002282397,0.0001857475,0.0002461746,0.0005345214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001570834,"about_ca_system_score_gemma":0.0001291338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001412482,"about_ca_topic_score_gemma":0.0002870719,"domain_scores_codex":[0.9999105,0.00001197397,0.000005481279,0.00002815351,0.00003281935,0.00001114978],"domain_scores_gemma":[0.9999508,0.00001027554,0.00001181619,0.000004967221,0.000008210208,0.0000139287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005761415,0.00002197006,0.0001339301,0.00004194686,0.000007972928,0.00008000848,0.00001673015,0.000627169,0.9915656,0.0004235497,0.0001392872,0.006884299],"study_design_scores_gemma":[0.00001807228,0.0002796561,0.0003091304,0.000001830222,0.00001798576,0.0002405871,0.000008433511,0.004630575,0.989702,0.00009283282,0.004691998,0.000006984822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708796,0.002924449,0.01850646,0.0003226634,0.00007804479,0.00003820409,0.00008413783,0.0004493322,0.006717249],"genre_scores_gemma":[0.9856954,0.0004328902,0.009059311,0.0001003521,0.00001311093,0.00001219285,0.00007569806,0.00002573391,0.004585251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080996,"threshold_uncertainty_score":0.003616273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005616649791362909,"score_gpt":0.2634659758075958,"score_spread":0.2578493260162329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}