{"id":"W2054425531","doi":"10.1021/bi0609624","title":"The Transferable Tail:  Fusion of the N-Terminal Acidic Extension of Heparin Cofactor II to α<sub>1</sub>-Proteinase Inhibitor M358R Specifically Increases the Rate of Thrombin Inhibition","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Blood Services","funders":"","keywords":"Serpin; Heparin cofactor II; Chemistry; Thrombin; Biochemistry; Proteases; Pi; Protein C; Trypsin; Stereochemistry; Enzyme; Heparin; Antithrombin; Biology; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009730321,0.0004044376,0.0001861326,0.00008242451,0.00006393605,0.0002218477,0.0002962067,0.0003076205,0.001495199],"category_scores_gemma":[0.0001167846,0.00009595205,0.000234894,0.0001136519,0.0002284435,0.0001539224,0.0001781909,0.0004240208,0.0007196653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185069,"about_ca_system_score_gemma":0.0001050706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006552269,"about_ca_topic_score_gemma":0.0005071239,"domain_scores_codex":[0.9998964,0.00001253925,0.000008173217,0.00003429442,0.00002029511,0.00002822772],"domain_scores_gemma":[0.9999223,0.00001131841,0.00003495309,0.000009234737,0.000005537828,0.00001679965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006605982,0.000009452381,0.00006723142,0.00001123556,0.000004252387,0.00002287691,0.00000521247,0.00004659885,0.9989064,0.00004757452,0.00002766945,0.000785323],"study_design_scores_gemma":[0.00001420287,0.0001327068,0.001331008,0.000002383472,0.00001289395,0.0002342672,0.000003891463,0.0005105918,0.9951716,0.00001051447,0.002572393,0.000003476071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990606,0.001337143,0.006107941,0.00005989146,0.00004378298,0.0000458658,0.0004069907,0.0001835467,0.001208867],"genre_scores_gemma":[0.9931998,0.0003054952,0.003399392,0.00005193609,0.00001245271,0.00002162117,0.0005707886,0.00003263072,0.002405986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001495199,"threshold_uncertainty_score":0.005001962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006461495390838396,"score_gpt":0.2019274661194122,"score_spread":0.1954659707285738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}